Evidence map›Paper›PMID 42147271›Full record

ArticleRegenerative biomaterials2026

A dual-functional injectable polysaccharide hydrogel incorporating oxygen-carrying nanoemulsion and VEGF for enhancing islet survival and glycemic control in diabetic mice.

Yuwei Zhang, Zhaoyu Sun, Miao Liu, Jinxin Pang, Shanshan Huang, Hongyang Liu, Huabin Zheng, Siyu Guan, Jie Li, Yifan Feng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuwei ZhangKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Zhaoyu SunKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Miao LiuKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Jinxin PangKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Shanshan HuangKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Hongyang LiuKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Huabin ZhengKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Siyu GuanKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Jie LiKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Yifan FengKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Jiang OuyangGuangzhou Institute of Cancer Research, The Affiliated Cancer Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou 510180, China.
Tao XuKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.ORCID https://orcid.org/0000-0002-8260-9754
Wen DuKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital & School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes (T1D) arises from autoimmune destruction of pancreatic β-cells, leading to lifelong dependence on exogenous insulin. Clinical islet transplantation offers a potential cure by restoring endogenous insulin secretion; however, its success is critically limited by poor post-transplant vascularization and oxygen deprivation, which cause over 70% of transplanted islets to undergo early necrosis or apoptosis. To address these challenges, we developed an injectable, biodegradable dual-functional hydrogel composed of oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMC). This polysaccharide-based platform co-delivers vascular endothelial growth factor (VEGF) and an oxygen-carrying perfluorotributylamine (PFTBA) nanoemulsion, enabling simultaneous enhancement of angiogenesis and oxygenation within the graft microenvironment. The OHA/CMC hydrogel exhibited excellent biocompatibility, tunable gelation and sustained release of both oxygen and VEGF.

Indexed as

hydrogelislet transplantationtype 1 diabetes

Identifiers

PMID42147271
PMCPMC13175250

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.