ArticleFrontiers in pharmacology2026
Isavuconazole therapeutic drug monitoring in real-world clinical practice: an age-stratified analysis of determinants.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Although therapeutic drug monitoring (TDM) for isavuconazole (ISA) is not routinely recommended, its utility in specific populations remains debated. This study aimed to elucidate the need for ISA TDM and to identify the specific patient groups who might benefit from it. Methods: We retrospectively analyzed 48 patients (13 pediatric, 19 non-elderly, 16 elderly) who underwent ISA TDM. Clinical characteristics, TDM results, dose adjustments, and outcomes were collected. Results: A total of 179 trough measurements were obtained. Pediatric patients had a lowest median C Conclusion: TDM helps optimize dosing, especially in populations with high variability such as pediatric patients. Female sex, ICU admission, and RRT are important factors associated with lower exposure in elderly patients.
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