ArticleMolecular therapy. Advances2026
The good, the bad, and the stable: Reference genes for preclinical biodistribution studies.
Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Digital PCR (dPCR) enables absolute, precise nucleic acid quantification without the need for standard curves. Still, technical variability across the sample life cycle remains a challenge in complex multi-organ preclinical studies. This study evaluated the necessity of internal reference genes (i.e., housekeeping genes; HKGs) for normalizing reverse transcription (RT)-dPCR data from recombinant adeno-associated virus (rAAV) studies in mice and non-human primates (NHPs). HKGs were ranked using statistical analysis and further evaluated with the BestKeeper and geNorm algorithms. In mice,
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