ArticleFrontiers in bioengineering and biotechnology2026
Adhesive hydrogel-enabled integrative fixation for cartilage and osteochondral repair.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Secure attachment of repair constructs to native cartilage and underlying bone tissues remains a major unmet need in chondral and osteochondral surgery. Currently existing injectable or scaffold-based cell carriers, while biologically compatible, lack the mechanical integrity and interfacial adhesion. In most cases, a secondary fixation using suturing or fibrin glue remains necessary, which can be challenging in terms of achieving long-term integration and reproducible clinical outcomes. Here, we investigated the biomechanical and adhesive performance of our previously developed photo-curable phosphoserine-functionalized methacrylated gelatin hydrogel, with the aim of defining a clinically relevant formulation window for integrative fixation. Polymer content (PC) was varied to control cohesive and interfacial properties. The hydrogel exhibited tunable biomechanical performance across formulations, with no significant batch-to-batch variability. Autoclave sterilization reduced stiffness and adhesion but preserved overall mechanical integrity, with sterilization before lyophilization (T1) causing smaller performance losses than sterilization after precursor preparation (T2).
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