Evidence map›Paper›PMID 42147490›Full record

ArticleCell press blue2026

An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity.

Bruno F Matuck, Khoa L A Huynh, Diana Pereira, Quinn T Easter, XiuYu Zhang, Meik Kunz, Nikhil Kumar, Aditya Pratapa, Brittany T Rupp, Ameer Ghodke and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell press blue, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Bruno F MatuckDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.
Khoa L A HuynhDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA.
Diana PereiraCenter for Oral Immunobiology and Regenerative Medicine, Barts Centre for Squamous Cancer, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Quinn T EasterDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.
XiuYu ZhangDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA.
Meik KunzThe Bioinformatics CRO, Sanford, FL, USA.
Nikhil KumarDivision of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Aditya PratapaDepartment of Cell Biology, Duke University, Durham, NC, USA.
Brittany T RuppDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.
Ameer GhodkeDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Alexander V PredeusWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Alexandre FernandesCenter for Oral Immunobiology and Regenerative Medicine, Barts Centre for Squamous Cancer, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Lili SzabóMildred-Scheel Early Career Centre (MSNZ) for Cancer Research, University Hospital Wuerzburg, Wuerzburg, Germany.
Stefan HartmannDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Würzburg, Germany.
Nadja HarnischfegerMildred-Scheel Early Career Centre (MSNZ) for Cancer Research, University Hospital Wuerzburg, Wuerzburg, Germany.
Zohreh KhavandgarSjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA.
Margaret BeachSjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA.
Paola PerezSjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA.
Benedikt NilgesOMAPiX, Inc, Leuven, Belgium.
Maria M MorenoOMAPiX, Inc, Leuven, Belgium.
Kang I KoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rohit SinghDepartment of Cell Biology, Duke University, Durham, NC, USA.
Purushothama Rao TataDepartment of Cell Biology, Duke University, Durham, NC, USA.
Sarah A TeichmannCambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Adam KimpleDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Sarah PringleUniversity of Groningen and University Medical Center, Groningen, the Netherlands.
Kai KretzschmarMildred-Scheel Early Career Centre (MSNZ) for Cancer Research, University Hospital Wuerzburg, Wuerzburg, Germany.
Blake M WarnerSjögren's Clinical Investigations Team, National Institutes of Dental and Craniofacial Research, Bethesda, MD, USA.
Inês SequeiraCenter for Oral Immunobiology and Regenerative Medicine, Barts Centre for Squamous Cancer, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jinze LiuDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA.
Kevin M ByrdDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
Molecular control of a novel transitional cell state in alveolar regenerationR01HL153375 · NHLBI · DUKE UNIVERSITY · PI Purushothama Rao Tata · 2020 to 2026
$3.4M
Clinical Investigations Of Sjogren's SyndromeZ01DE000704 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ILLEI, GABOR · 2002 to 2008
$3.0M
A Team Science Approach to the Co Development of Oral Mucosa for Therapeutic PurposesRM1DE035338 · NIDCR · CEDARS-SINAI MEDICAL CENTER · PI Kevin Matthew Byrd, Zev Jordan Gartner · 2025 to 2026
$2.4M
Cellular crosstalk and molecular mechanisms in the initiation and progression of pulmonary fibrosisR01HL160939 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2022 to 2025
$2.1M
Mechanisms of submucosal gland cell mediated airway regenerationR01HL146557 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2019 to 2023
$2.0M
Intramural NIH HHS Z01 DE000704NCI NIH HHS P30 CA016059NHLBI NIH HHS R01 HL146557NHLBI NIH HHS R01 HL153375NHLBI NIH HHS R01 HL160939NIDCR NIH HHS RM1 DE035338
6 · The paper itself

Abstract

The immunoregulatory architecture of human oral tissues remains poorly defined. We present an integrated single-cell and spatial proteotranscriptomic atlas profiling >250,000 single-cell transcriptomes and >4 million spatially resolved cells across 13 niches. Using our AI-enabled AstroSuite, we defined neighborhoods and interaction modules, revealing peri-epithelial fibroblast-centered hubs enriched in effector cytokines. We harmonized fibroblast subtypes (universal, immune, peri-epithelial, peri-vascular, peri-neural, antigen-presenting cell [APC]-like, stress responsive, and myofibroblasts) with stress-responsive subtypes partitioning between mucosae and glands (type I and II). Spatial multiomics mapped ligand-receptor programs and identified mucosal stress-responsive fibroblasts as putative immunoregulatory hubs. Niche-aware integration of healthy and diseased datasets revealed fibroblast rewiring into inflammatory and reparative niches. Disease neighborhoods exhibited expansion of major histocompatibility complex (MHC)-I

Identifiers

PMID42147490
PMCPMC13179517

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.