Evidence map›Paper›PMID 42147813›Full record

ArticleHuman mutation2026

The miR-146a/

Xiao Chen, Dan Wang, Jing Du, Jiale Li, Zihe Wang, Binbin Chen, Xueqing Yao, Shuangfeng Li, Na Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The miR-146a/Human mutation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao ChenDepartment of Anesthesiology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China, hainmc.edu.cn.
Dan WangDepartment of Anesthesiology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China, hainmc.edu.cn.
Jing DuDepartment of Anesthesiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China, hainmc.edu.cn.ORCID https://orcid.org/0009-0003-4280-4461
Jiale LiDepartment of Anesthesiology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China, hainmc.edu.cn.ORCID https://orcid.org/0009-0007-4333-2979
Zihe WangMedical Laboratory Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China, hainmc.edu.cn.ORCID https://orcid.org/0009-0000-6299-0263
Binbin ChenDepartment of Anesthesiology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China, hainmc.edu.cn.ORCID https://orcid.org/0009-0006-0985-2789
Xueqing YaoDepartment of Anesthesiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China, hainmc.edu.cn.ORCID https://orcid.org/0009-0006-0858-4284
Shuangfeng LiDepartment of Anesthesiology, Haikou Maternal and Child Health Hospital, Haikou, China.ORCID https://orcid.org/0000-0002-7890-8428
Na LiDepartment of Anesthesiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China, hainmc.edu.cn.ORCID https://orcid.org/0000-0003-2567-3351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study comprehensively examined the mechanism of the roles of dexmedetomidine (Dex) and miR-146a in chronic obstructive pulmonary disease (COPD). Methods: COPD models were established employing cigarette smoke extract (CSE)-exposed airway epithelium cell 16HBE and cigarette smoke-treated Sprague-Dawley rats, followed by interference with Dex and transfection. CCK-8 and flow cytometry assays were employed for the detection of cell viability and apoptosis. Further, the levels of factors related to the NF- Results: Dex and miR-146a mimic notably inhibited the inflammation and apoptosis of CSE-induced 16HBE cells via modulating the levels of TNF- Conclusion: Our in vitro and in vivo studies showed that Dex alleviated CSE-induced COPD via modulating the miR-146a/

Indexed as

DexmedetomidineMicroRNAsPulmonary Disease, Chronic ObstructiveAnimalsApoptosisCell LineCigarette SmokingDisease Models, AnimalGene Expression RegulationHumansMaleNF-kappa BRatsRats, Sprague-DawleySignal TransductionSmokeDexmedetomidineMicroRNAsMIRN146a microRNA, ratMIRN146 microRNA, humanMIRN146 microRNA, ratNF-kappa BSmokechronic obstructive pulmonary diseasecigarette smoke extractdexmedetomidineimmunoglobulin superfamily Member 11microRNA-146a

Identifiers

PMID42147813
PMCPMC13171721

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.