ArticleBalkan journal of medical genetics : BJMG2025
Exploratory Analysis of Sex-Related Immune Gene Expression in Patients With Severe Periodontitis.
Article in Balkan journal of medical genetics : BJMG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Biological sex influences immune function and inflammatory regulation, but its molecular role in periodontal disease remains insufficiently understood. This pilot study investigated sex-dependent differences in immune gene expression in patients with severe periodontitis. Methods: Ten systemically healthy, non-smoking adults (five men and five women) with stage III/IV periodontitis were examined. Total RNA was extracted from saliva and analyzed using the nCounter Results: Among 249 immune-related genes analyzed, two showed notable preliminary trends of sex-associated differences: Conclusion: These exploratory results suggest hypothesis-generating trends regarding sex-dependent differences in epithelial repair and innate immunity, highlighting
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