Evidence map›Paper›PMID 42148089›Full record

ArticleFrontiers in immunology2026

CFD

Shuang Li, Yifan Zhang, Chenlu Hou, Ting Chang

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shuang LiDepartment of Neurology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Yifan ZhangDepartment of Neurology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Chenlu HouDepartment of Neurology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Ting ChangDepartment of Neurology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Transcriptome-wide association study (TWAS) contributes to discovering novel susceptibility genes related to diseases. Single-cell RNA sequencing (scRNA-seq) has been extensively applied to characterize cellular heterogeneity in various biological and pathological conditions. However, few studies have integrated TWAS and scRNA-seq to decode the pathogenesis of myasthenia gravis (MG) at cellular resolution. Methods: We integrated multi-omics data from GEO, genome-wide association study (GWAS) catalog, and Genotype-Tissue Expression (GTEx) databases, including scRNA-seq data, GWAS summary data, and expression quantitative trait loci. A set of risk genes genetically associated with MG were identifies using TWAS analysis. TWAS activity status across cell types in MG at single cell resolution was assessed based on these genes. Seven machine learning algorithms were performed to identify high TWAS activity related signature genes. Machine learning benchmark was incorporated to select the best model using R package "mlr3". Meanwhile, we performed scRNA-seq on peripheral blood collected from MG patients and healthy controls to generate a validation dataset. Results: scRNA-seq analysis revealed an elevated proportion of CD14 Conclusion: In summary, this study systematically delineates the important role of CFD

Indexed as

Lipopolysaccharide ReceptorsMachine LearningMonocytesMyasthenia GravisFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMultiomicsRNA-SeqSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTranscriptomeCD14 protein, humanLipopolysaccharide ReceptorsCFDmachine learningmyasthenia gravisscRNA-seqTWAS

Identifiers

PMID42148089
PMCPMC13176296

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.