SynthesisFrontiers in immunology2026
Immunological landscape of nanotechnology-based depression research: a bibliometric analysis of neuroinflammation and immune modulation.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Immune dysregulation and neuroinflammation have been increasingly implicated in depression, and nanotechnology-based approaches are being actively explored for targeted delivery and immunomodulation. However, a systematic, immune-oriented bibliometric mapping of research at the intersection of nanotechnology and depression remains limited. This study aims to characterize the publication landscape, collaboration patterns, and thematic evolution of this field using bibliometric evidence. Methods: Relevant publications (up to December 8, 2025) were retrieved from the Web of Science Core Collection and Scopus. Bibliometric visualization and network analyses were performed using Bibliometrix, VOSviewer, and CiteSpace to examine publication trends, global collaborations, core journals, and immune-related research themes. Results: A total of 591 publications were included, showing marked growth after 2020. China and the United States were leading contributors in publication output and citation impact. Keyword co-occurrence, burst detection, and co-citation analyses indicated a thematic evolution from earlier emphases on neurotransmitter-related delivery/stabilization toward increasing attention to neuroinflammation- and immune-modulation-related topics. Recent hotspots and bursts were frequently associated with microglial biology/polarization, oxidative stress, and pro-inflammatory cytokines. Conclusion: This bibliometric study provides a descriptive overview of how research attention within nanotechnology and depression has evolved, with increasing prominence of immune- and neuroinflammation-related themes. These trend-based findings may help prioritize directions for future experimental and translational investigations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.