ArticleJournal of ophthalmology2026
LncRNA TINCR rs2288947 Polymorphism as a Genetic Susceptibility Factor for Diabetic Retinopathy.
Article in Journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- LncRNA TINCR rs2288947 Polymorphism as a Genetic Susceptibility Factor for Diabetic Retinopathy.Journal of ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Long noncoding RNAs (lncRNAs) are critically involved in the pathogenesis of diabetic retinopathy (DR). Nevertheless, the role of lncRNA TINCR in DR has not been fully elucidated. Objective: This study aimed to examine the relationship between the lncRNA TINCR polymorphism rs2288947 and DR susceptibility in a Chinese Han population with Type 2 diabetes mellitus (T2DM) and to explore the diagnostic potential of plasma lncRNA TINCR levels. Methods: A case-control study was conducted with 507 participants (255 NPDR patients and 252 T2DM controls). Plasma TINCR expression was measured via qRT-PCR, and rs2288947 genotyping was performed using the TaqMan assay. Multivariate logistic regression and ROC analyses were applied to evaluate diagnostic value and risk associations. Results: LncRNA TINCR expression was significantly elevated and served as an independent risk factor in NPDR patients and exhibited high diagnostic value. The Conclusion: Both lncRNA TINCR and the rs2288947 polymorphism contribute to NPDR development and show promise as biomarkers for early screening and risk evaluation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.