ArticleRSC advances2026
Development of coumarin-sulfonate scaffolds for cholinesterase inhibition: experimental and computational studies toward Alzheimer's disease therapy.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
The development of effective cholinesterase inhibitors remains a key strategy for the symptomatic management of Alzheimer's disease (AD); however, the identification of structurally versatile scaffolds capable of dual AChE/BChE inhibition remains limited. In this context, coumarin-sulfonate hybrids offer a promising framework for exploring structure-activity relationships due to their tunable electronic and steric properties. In the present study, a series of nine coumarin-sulfonate derivatives (1-9) were synthesized
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