Evidence map›Paper›PMID 42148574›Full record

ArticleMicrobiology spectrum2026

Comparative performance of L1- and E6/E7-targeted HPV genotyping assays based on a unified MeltArray platform.

Yuli Liu, Huihui Qu, Feng Zhang, Shuyang Gan, Yongqing Lai, Xiaoxing Zhang, Meiying Zhong, Xinyi Yang, Ye Xu, Yiqun Liao and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuli Liu *State Key Laboratory of Vaccines for Infectious Diseases, Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Public Health, Xiamen University, Xiamen, China.
Huihui Qu *State Key Laboratory of Vaccines for Infectious Diseases, Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Public Health, Xiamen University, Xiamen, China.
Feng ZhangEngineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Life Sciences, Xiamen University, Xiamen, China.
Shuyang GanState Key Laboratory of Vaccines for Infectious Diseases, Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Public Health, Xiamen University, Xiamen, China.
Yongqing LaiFujian Engineering Research Center of Nucleic Acid Detection Technologies, Fujian, China.
Xiaoxing ZhangState Key Laboratory of Vaccines for Infectious Diseases, Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Public Health, Xiamen University, Xiamen, China.
Meiying ZhongState Key Laboratory of Vaccines for Infectious Diseases, Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Public Health, Xiamen University, Xiamen, China.
Xinyi YangState Key Laboratory of Vaccines for Infectious Diseases, Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Public Health, Xiamen University, Xiamen, China.
Ye XuEngineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0001-5066-4698
Yiqun LiaoState Key Laboratory of Vaccines for Infectious Diseases, Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Public Health, Xiamen University, Xiamen, China.ORCID 0000-0003-2585-0688
Qingge LiEngineering Research Center of Molecular Diagnostics of the Ministry of Education, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0002-3431-138X

Funding

Key Science and Technology Major Project of Xiamen 3502Z20231025Natural Science and Technology Major Project of the Xiamen 3502Z20231034Natural Science Project of the Xiamen 3502Z202473018
6 · The paper itself

Abstract

Human papillomavirus (HPV) molecular testing is central to cervical cancer screening. Commercial assays commonly target either the L1 gene or the E6/E7 oncogenes, yet comparative performance data under standardized conditions remain limited. We developed two HPV genotyping assays targeting L1 and E6/E7 regions, respectively, using the same MeltArray platform to minimize technical variability. Both assays detect 18 high-risk and potential high-risk HPV types. A total of 2,477 clinical samples (2,034 liquid-based cytology [LBC] and 413 formalin-fixed paraffin-embedded [FFPE] specimens) were analyzed. Concordance in HPV detection and genotyping was assessed using Cohen's kappa statistics. The assays showed 98.8% overall agreement in HPV detection (Cohen's kappa [

Indexed as

Capsid ProteinsGenotyping TechniquesHuman Papillomavirus VirusesOncogene Proteins, ViralPapillomaviridaePapillomavirus InfectionsAdultEarly Detection of CancerFemaleGenotypeHumansMiddle AgedSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsCapsid ProteinsOncogene Proteins, ViralE6/E7 genesgenotypinghuman papillomavirusL1 geneMeltArray

Identifiers

PMID42148574
PMCPMC13340185

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.