Evidence map›Paper›PMID 42148773›Full record

ArticlemSystems2026

Canonical transcription termination mechanisms explain a minority of operons in cyanobacteria.

Jennifer A Cascino, K Julia Dierksheide, Rishi K Vishwakarma, Yulia Yuzenkova, Paul Babitzke, Katsuhiko S Murakami, Gene-Wei Li

Abstract read
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jennifer A Cascino *Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-0404-7557
K Julia Dierksheide *Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0009-0004-0946-2655
Rishi K VishwakarmaDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Yulia YuzenkovaCentre for Bacterial Cell Biology, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Paul BabitzkeDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-2481-1062
Katsuhiko S MurakamiDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-2244-0501
Gene-Wei LiDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0001-7036-8511

Funding

Pre-doctoral Training in Fundamental Approaches to Biochemistry and Cell and Molecular BiologyT32GM136540 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Mary Gehring, Michael Laub · 2021 to 2026
$9.5M
Evolution and Regulation of Bacterial Proteome CompositionR35GM124732 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gene-Wei Li · 2017 to 2026
$3.8M
Regulation of transcription elongationR01GM098399 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BABITZKE, PAUL L · 2012 to 2024
$3.6M
Post-transcription Initiation Control of Gene ExpressionR35GM153190 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PAUL L BABITZKE · 2024 to 2026
$1.3M
Structural study of direct associations between cellular RNA polymerase and regulatory factors during the transcription cycleR35GM156623 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Katsuhiko Murakami · 2025 to 2026
$903k
MathWorks Graduate FellowshipNIGMS NIH HHS R01 GM098399NIGMS NIH HHS R35 GM153190NIH HHS R35GM124732NIH HHS R35GM153190NIH HHS R35GM156623NIH HHS T32GM136540Pew Charitable Trusts Innovation FundUK Research and Innovation Mission Award BB/Y007638/1
6 · The paper itself

Abstract

Cyanobacteria are abundant phototrophs and hold potential as a carbon-negative platform for bioengineering applications. However, these efforts have been hampered by limited mechanistic understanding of their gene expression, including transcription termination. Unlike most bacteria, cyanobacteria lack the transcription termination factor Rho, raising the speculation that all transcription ends with intrinsic terminators. Here, we show that most transcription units (TUs) in IMPORTANCE: Our understanding of bacterial transcription regulation is largely based on model organisms like

Indexed as

OperonSynechococcusTranscription Termination, GeneticBacterial ProteinsGene Expression Regulation, BacterialRNA, BacterialTerminator Regions, GeneticTranscription, GeneticBacterial ProteinsRNA, Bacterialcyanobacteriagene regulationintrinsic terminationMfdpicocyanobacteriaRNA sequencingtranscriptiontranscriptional regulationtranscription terminationtranscriptomics

Identifiers

PMID42148773
PMCPMC13289151

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.