Evidence map›Paper›PMID 42148776›Full record

ArticlemSystems2026

Jing Guo, Zhong-Wen Xiang, Fang-Fang Hu, Song-Xia Zhang, Wen-Jing Han, Xin Ding, Xin Wang, Meng-Ling Ye, Jun-Hong Chen, Tai Rao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jing GuoDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0009-0000-3021-4075
Zhong-Wen XiangDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fang-Fang HuDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Song-Xia ZhangDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wen-Jing HanDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xin DingDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xin WangDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Meng-Ling YeDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jun-Hong ChenDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tai RaoDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lie-Lin WuDepartment of Organ Transplantation, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guang-Hui LianDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wei ZhangDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yun HuangDepartment of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0001-8517-0516
Yao ChenDepartment of Clinical Pharmacology, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0001-7231-9860

Funding

Fundamental Research Funds for Central Universities of the Central South University 2025ZZTS0793National Natural Science Foundation of China 82373960, 81974513Natural Science Foundation of Hunan Province 2023JJ30891, 2025JJ50675, 2026JJ50342
6 · The paper itself

Abstract

Emerging evidence points to the gut microbiota's involvement in metabolic dysfunction-associated steatohepatitis (MASH), yet the specific causative microbes remain largely unidentified. This study aimed to identify and functionally characterize candidate microbial pathobionts to MASH progression. Differentially abundant microbes were identified by 16S rRNA sequencing in a choline-deficient, L-amino acid-defined, high-fat diet MASH model, validated in other animal MASH models and in public clinical metagenomic data sets, then screened for consistently altered gut taxa. A candidate underwent functional validation via directed oral administration in mice. Mechanisms were explored through bile acid profiling by UHPLC-MS/MS and FXR signaling analysis by qPCR and immunohistochemistry. Additionally, fecal samples from MASH patients before and after treatment were analyzed to correlate microbial abundance with treatment response. IMPORTANCE: Metabolic dysfunction-associated steatohepatitis (MASH) is a growing global health problem with limited treatment options. Although the gut microbiome has been implicated in MASH, the specific bacterial strains that directly drive disease progression remain largely unknown. This study identified

Indexed as

Fatty LiverGastrointestinal MicrobiomeAnimalsBile Acids and SaltsCholesterol 7-alpha-HydroxylaseDiet, High-FatDisease Models, AnimalHumansLiverMaleMiceMice, Inbred C57BLReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearRNA, Ribosomal, 16SSignal TransductionBile Acids and SaltsCholesterol 7-alpha-HydroxylaseReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearRNA, Ribosomal, 16Sbile acidFXRMASHTuricibacter sanguinis

Identifiers

PMID42148776
PMCPMC13289106

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.