Evidence map›Paper›PMID 42148803›Full record

ReviewCell cycle (Georgetown, Tex.)2026

Circular RNAs in tumorigenesis: an insight into recent research in biogenesis and targeted tumor therapy.

Zahra Shafaghat, Pezhman Golshanrad, Saber Saharkhiz, Anna Leśniak, David Mikeladze, Nelly Datukishvili, Marzieh Ramezani Farani, Iraj Alipourfard

Abstract readReview
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zahra ShafaghatDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Pezhman GolshanradDepartment of Computer Engineering, Sharif University of Technology (International Campus), Tehran, Iran.
Saber SaharkhizDivision of Neuroscience, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Anna LeśniakDepartment of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.
David MikeladzeLaboratory of Genome Structure and Function, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
Nelly DatukishviliLaboratory of Genome Structure and Function, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
Marzieh Ramezani FaraniNano Bio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Inha-ro, Incheon, Republic of Korea.
Iraj AlipourfardDepartment of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0001-5164-8606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are eukaryotic RNA molecules that are covalently closed and have the characteristics of high stability, tissue-specific expression, and cell-specific expression. The majority of circRNAs are produced from pre-mRNAs that also result in linear RNA, and they have expression patterns that are similar to those of their host mRNAs. Despite their abundance, circRNAs are typically expressed at lower levels than mRNAs. These molecules are often dysregulated in Cancer and play important roles during the beginning and progression of tumors, according to mounting data. Dysregulated circRNAs unique to Cancer may be used as biomarkers for cancer diagnosis and prognosis since certain circRNAs from cancer tissues have been shown to go through the bloodstream and be persistently present in sera. It has been discovered that circRNAs not only influence tumor immunity and play a major role in tumor indicators, tumor development, and prognosis, but they may also be expressed improperly in various tumors.

Indexed as

CarcinogenesisMolecular Targeted TherapyNeoplasmsRNAAnimalsBiomarkers, TumorGene Expression Regulation, NeoplasticHumansRNA, CircularBiomarkers, TumorRNARNA, Circularcancer immunotherapyCircRNAncRNARNA splicingtumor microenvironment

Identifiers

PMID42148803
PMCPMC13185442

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.