Evidence map›Paper›PMID 42149084›Full record

ArticleChemistry, an Asian journal2026

Conformationally Defined Alkaloidal Building Units for the Controlled Formation of Nanoscale Supramolecular Morphologies.

Fumi Oki, Shunsuke Murakami, Tasuku Honda, Satoshi Yoshida, Saori Maki-Yonekura, Jungmin Kang, Kensuke Tono, Koji Yonekura, Sota Sato, Hiroki Oguri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fumi OkiDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Shunsuke MurakamiDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Tasuku HondaDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Satoshi YoshidaDepartment of Applied Chemistry, School of Engineering, The University of Tokyo, Kashiwa, Japan.
Saori Maki-YonekuraRIKEN SPring-8 Center, Sayo, Japan.
Jungmin KangRIKEN SPring-8 Center, Sayo, Japan.
Kensuke TonoRIKEN SPring-8 Center, Sayo, Japan.
Koji YonekuraRIKEN SPring-8 Center, Sayo, Japan.
Sota SatoDepartment of Applied Chemistry, School of Engineering, The University of Tokyo, Kashiwa, Japan.
Hiroki OguriDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Funding

AMED JP23ama121006Asahi Glass FoundationJSPS KAKENHI JP22H00346JSPS KAKENHI JP22H05127JST-Mirai Program JPMJMI23G2Ministry of Education, Culture, Sports, Science and Technology JPMXP1225UT0201Program for JST SPRING JPMJSP2108
6 · The paper itself

Abstract

Precise control over nanoscale morphologies is essential for designing advanced supramolecular systems with programmed functions. Among various molecular motifs, diketopiperazine (DKP) stands out as a promising building block due to its robust hydrogen-bonding capability. Inspired by natural products containing DKP units, we developed supramolecular assemblies based on bispyrrolidinoindoline (BPI) scaffolds fused with DKP rings. By exploiting the conformational tunability of BPI scaffolds arising from rotation around the C3a─3a' bond, we achieved precise modulation of their three-dimensional conformations and self-assembly behavior through dual substituent and stereochemical modifications. Iodination at the C5/5' positions refined conformational preferences and promoted the formation of highly ordered nano-structures. Moreover, additional stereochemical modification at the C15/15' positions successfully shifted the morphology from block-like to fibrous assemblies. These findings underscore the pivotal roles of substituent and stereochemistry in controlling nanoscale morphology, positioning BPI-based scaffolds as a versatile platform for supramolecular engineering.

Indexed as

chiral alkaloidal scaffoldsconformational controlnatural productsprogrammable nanoscale morphologiesself‐assembly

Identifiers

PMID42149084
PMCPMC13182762

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.