Evidence map›Paper›PMID 42149490›Full record

ArticleThe Journal of infectious diseases2026

Proportional Odds or Win Probability as Methods for Assessing Ordinal Outcomes in Infectious Disease Clinical Trials.

Linda J Harrison, Felicia C Chow

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Linda J HarrisonCenter for Biostatistics in AIDS Research, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-3170-0865
Felicia C ChowWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-9440-9349

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
Reimagining the IMAGINE-TBM trial: Using metagenomics and host transcriptomics to improve our ability to diagnose tuberculous meningitis and assess response to treatment in a randomized clinical trialR01NS134054 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Felicia C. Chow, Vidya Mave · 2025 to 2026
$1.5M
National Institute of Allergy and Infectious DiseasesNIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI106701NIH HHS UM1 AI068634NIH HHS UM1 AI068636NIH HHS UM1 AI106701NINDS NIH HHS R01 NS134054
6 · The paper itself

Abstract

Infectious disease trials have long used ordinal outcomes, or ranked categorical scales, to capture the full spectrum of response to an intervention. We review 2 summary statistics for ordinal outcomes: the proportional odds ratio (pOR) and the win probability. The pOR asks: How much more likely is a treated participant to be in an improved category compared with control? The win probability asks: In a random treatment-control pair, what is the chance the treated participant fares better? We also introduce visual companions, the stacked-bar chart and bubble plot, to make ordinal trial results more accessible and interpretable.

Indexed as

clinical trialsinfectious diseaseordinal outcomesproportional odds ratiowin probability

Identifiers

PMID42149490
PMCPMC13557038

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.