Evidence map›Paper›PMID 42149864›Full record

ArticlePloS one2026

Relationship of glycemic variability with delirium and mortality among critically ill elderly patients with sepsis: A retrospective matched cohort study.

Jianqin Huang, Jiexuan Xu, Yu Zhai, Shuting Liu, Pengcheng Duan, Jiayan Liang, Yile Tian, Murong Lu, Xuemei Liu, Hongjing Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianqin HuangIntensive Care Unit, The Second Affiliated Hospital Of Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0002-9457-2511
Jiexuan XuIntensive Care Unit, The Second Affiliated Hospital Of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yu ZhaiDepartment Of Cardiovascular Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Shuting LiuIntensive Care Unit, The Second Affiliated Hospital Of Guangzhou Medical University, Guangzhou, Guangdong, China.
Pengcheng DuanNursing Administration Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Jiayan LiangDepartment Of Cardiovascular Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yile TianDepartment Of Cardiovascular Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0000-6557-9621
Murong LuIntensive Care Unit, The Second Affiliated Hospital Of Guangzhou Medical University, Guangzhou, Guangdong, China.
Xuemei LiuNursing Administration Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Hongjing YuNursing Administration Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-0547-5921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe associations of glycemic variability (GV) with the occurrence of delirium and 90-day and 180-day mortality in critically ill patients with sepsis remain unclear. This study aimed to investigate the associations of glycemic variability with the development of delirium and death.

methodThis study employed a retrospective analysis of elderly sepsis patients admitted to the intensive care unit (ICU) for the first time. Patients were categorized into two groups based on their GV: a high-risk group (< 21.399%) and a low-risk group (≥21.39%). The relationship between GV and delirium was assessed via logistic regression and restricted cubic splines. Cox regression was employed to analyze the relationship between GV and patients' 90-day and 180-day mortality.

resultsThis study included 12228 elderly patients who were diagnosed with sepsis. The high-risk group presented a significantly elevated risk of delirium (27.9% vs 22.1%) and higher 90-day (40.0% vs 30.1%) and 180-day (46.0% vs 35.7%) mortality rates (all p < 0.001). The increase in GV was approximately nonlinear with increasing risk of delirium. In addition, high GV was associated with the greatest risk among delirium (OR = 1.122, 95% CI 1.023-1.230), 90-day mortality (HR = 1.149, 95% CI 1.07-1.227) and 180-day mortality (HR = 1.153, 95% CI 1.085-1.224) in elderly sepsis patients.

conclusionGV is independently associated increased risk of delirium and 90-day and 180-day mortality in elderly sepsis patients, indicating that GV can serve as a biomarker for identifying at higher risk of delirium and mortality in sepsis patients.

Indexed as

Blood GlucoseCritical IllnessDeliriumSepsisAgedAged, 80 and overFemaleHumansIntensive Care UnitsMaleRetrospective StudiesRisk FactorsBlood Glucose

Identifiers

PMID42149864
PMCPMC13183229

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.