Evidence map›Paper›PMID 42150306›Full record

ArticleEBioMedicine2026

Brain endothelial Gα

Dimitrios Spyropoulos, Lena Kleindienst, Phillip Ehrich, Dorothea Ziemens, Rentsenkhand Natsagdorj, Nicholas Noll, Cathrin Elly Hansen, Géza Adam Curley, Anne-Sophie Gutt, Ákos Menyhárt and 16 more

Abstract read
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In one paragraph

Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Dimitrios SpyropoulosInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.
Lena KleindienstInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.
Phillip EhrichInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Dorothea ZiemensInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.
Rentsenkhand NatsagdorjInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.
Nicholas NollInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Cathrin Elly HansenInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Géza Adam CurleyInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Anne-Sophie GuttInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Ákos MenyhártHungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary; Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Jan SedlacikDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Peter LudewigDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Beate LembrichInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Ümit ÖzorhanInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.
Evi KostenisMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Germany.
Jens FiehlerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Gereon HüttmannInstitute of Biomedical Optics, University of Lübeck, Lübeck, Germany; German Center of Lung Research (DZL), Lübeck, Germany.
Thomas Andrew LongdenDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, USA.
Ruben NogueirasDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Vincent PrevotUniversity of Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, DISTALZ, EGID, Lille, France.
Helge Müller-FielitzInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
Stefan OffermannsDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Nina WettschureckDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Eszter FarkasHungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary; Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Markus SchwaningerInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.
Jan WenzelInstitute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany. Electronic address: Jan.wenzel@uni-luebeck.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral small vessel disease (cSVD) is a major cause of stroke and dementia, and is associated with increased blood-brain barrier permeability, neuroinflammation, and endothelial dysfunction. Endothelial Gα

methodsHere, we generated mice carrying a brain endothelial-specific deletion of the Gα

findingsThe brain endothelial Gα

interpretationThese findings reflect the main hallmarks of cSVD and demonstrate a protective role of Gα

fundingResearch was supported by grants from the European Research Council, the Deutsche Forschungsgemeinschaft, the institutional priority program MI-VascAD of the University of Lübeck, and the Marie-Sklodowska-Curie European Union's Horizon 2020 research program.

Indexed as

AgingBrainCerebrovascular CirculationCognitionGTP-Binding Protein alpha Subunits, Gq-G11Signal TransductionAnimalsBlood-Brain BarrierEndothelial CellsMaleMiceMice, KnockoutGTP-Binding Protein alpha Subunits, Gq-G11Ageing populationBlood–brain barrierCerebral small vessel diseaseCerebrovascular reactivityDementiaG protein-coupled receptors

Identifiers

PMID42150306
PMCPMC13202589

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.