ReviewRMD open2026
Recombinant zoster vaccine in patients with inflammatory rheumatic diseases: efficacy, long-term protection and safety under immunosuppression.
Review in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Reduced humoral response to recombinant zoster vaccine in patients with SLE: a prospective cohort study across immune-mediated inflammatory diseases.Lupus science & medicine · 2026Article
- Herpes zoster vaccination uptake in rheumatic diseases: persistent implementation gap despite improved uptake.Rheumatology advances in practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with inflammatory rheumatic diseases (IRDs) have a substantially increased risk of herpes zoster (HZ), driven by underlying immune dysregulation and immunosuppressive therapy, particularly high-dose glucocorticoids, biologic disease-modifying antirheumatic drugs and Janus kinase inhibitors. The adjuvanted recombinant zoster vaccine (RZV) has shown high efficacy in preventing HZ in older adults and durable protection for at least 10 years. Emerging data in immunocompromised populations, including rheumatology cohorts, support clinically meaningful protection with an acceptable safety profile.Recent evidence includes randomised controlled trials demonstrating non-inferiority of RZV vs placebo for short-term flare risk in adults with IRDs on stable immunosuppression. Real-world cohort data also showed a marked reduction in HZ relapse after vaccination (approximately 95%), with very few flares and no serious vaccine-related events. In contrast, a pharmacovigilance analysis of 920 autoimmune patients identified an 8.5% flare incidence and a threefold increased reporting OR for post-RZV flares, particularly in systemic lupus erythematosus, underscoring the need for short-term monitoring and clear counselling rather than avoidance of vaccination.Updated recommendations from the European Alliance of Associations for Rheumatology, the American College of Rheumatology, the Advisory Committee on Immunisation Practices/Centers for Disease Control and Prevention and national bodies now support two doses of RZV for adults with IRD at increased HZ risk, including many receiving potent immunosuppression. This review summarises current evidence on the efficacy, effectiveness, durability and safety of RZV in IRD and interprets new data on vaccination-related autoimmune flares. It also proposes a practical vaccination strategy for rheumatology care and highlights key research gaps.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.