Evidence map›Paper›PMID 42151104›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study.

Lauren E Oberlin, Patricio Solis-Urra, Kelsey R Sewell, Audrey M Collins, Chaeryon Kang, Haiqing Huang, George Grove, Lu Wan, Arthur F Kramer, Edward McAuley and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lauren E OberlinNeuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA.ORCID https://orcid.org/0000-0001-9553-8070
Patricio Solis-UrraNeuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Kelsey R SewellNeuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Audrey M CollinsNeuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Chaeryon KangDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Haiqing HuangNeuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA.
George GroveDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lu WanNeuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Arthur F KramerBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA.
Edward McAuleyBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA.
Jeffrey M BurnsAlzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
Charles H HillmanInstitute for Cognitive and Brain Health, Northeastern University, Boston, Massachusetts, USA.
Eric D VidoniAlzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
Anna L MarslandDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Amanda Szabo-ReedAlzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
Renee J RogersDepartment of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, Kansas, USA.
Jill MorrisAlzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
Xuemei ZengDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas K KarikariDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John M JakicicDepartment of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, Kansas, USA.
Kirk I EricksonNeuroscience Institute, AdventHealth Research Institute, Orlando, Florida, USA.

Funding

Investigating Gains in Neurocognition in an Intervention Trial of Exercise SupplementR01AG053952 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURNS, JEFFREY MURRAY, ERICKSON, KIRK I · 2016 to 2020
$27.5M
Physical Activity and Dementia: Mechanisms of ActionR35AG072307 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2021 to 2025
$3.6M
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital TherapeuticsK23MH129882 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Lauren Elizabeth Oberlin · 2023 to 2026
$775k
NIA NIH HHS R01 AG053952NIA NIH HHS R35 AG072307NIA NIH HHS R35AG072307NIH HHS R01AG053952NIMH NIH HHS K23 MH129882NIMH NIH HHS K23MH129882
6 · The paper itself

Abstract

introductionPhysical activity (PA) and cardiorespiratory fitness (CRF) are associated with reduced risk of cognitive decline and dementia, yet their relationships with dementia-related pathophysiology remain unclear. In a community-dwelling older adult cohort, we examined associations between objectively measured PA, CRF, biomarkers of Alzheimer's disease (AD)-related pathology, and cognition.

methodsParticipants (n = 648, 71% female, age 69.88 ± 3.75) completed a comprehensive cognitive evaluation, objective assessments of moderate-to-vigorous PA (MVPA) and CRF (VO

resultsGreater MVPA (β = -0.107; p = 0.013) and CRF (β = -0.114; p = 0.027) were associated with lower NfL, but not Aβ PET, p-tau217, Aβ1-42/1-40, or GFAP. Aβ positivity moderated the CRF-NfL relationship, with higher CRF linked to lower NfL specifically among Aβ-positive individuals. NfL mediated relationships between MVPA, CRF, and cognitive performance in select domains. DISCUSSION: Neuroprotective benefits of PA may be conferred through mechanisms influencing neurodegeneration, particularly among those with emerging AD pathology.

Indexed as

Alzheimer DiseaseCardiorespiratory FitnessExerciseAgedAmyloid beta-PeptidesBiomarkersBrainCognitionFemaleGlial Fibrillary Acidic ProteinHumansMaleNeurofilament ProteinsNeuropsychological TestsPeptide FragmentsPositron-Emission TomographyAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau Proteinsaerobic fitnessamyloid positron emission tomographycognitionepisodic memoryexecutive functionmodifiable risk factorneuropathologyphysical activityplasma biomarkerspreclinical Alzheimer's disease

Identifiers

PMID42151104
PMCPMC13183585

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.