ArticleScientific reports2026
Synthesis and anti-antileishmanial profile of novel thiazolidine-4-one derivatives and molecular docking and molecular dynamics simulations studies.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Leishmaniasis is a severely neglected intracellular protozoan disease caused by infection with parasites of the Leishmania genus, affecting over 98 countries globally. Presently, the infection threatens the health of more than 350 million people globally, resulting in an estimated 60,000 deaths yearly from both visceral and cutaneous forms of the parasite. In present research, a novel series of thiazolidine-4-one analogues (7a-g) was synthesized and evaluated against Leishmania major. In vitro assays demonstrated using Leishmania major promastigotes and amastigotes, while cytotoxicity was assessed on the J
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