Modulation of Cell-to-Cell Adhesion and Interaction with the Extracellular Matrix in Microgravity Conditions.

Elena Di Nisio, Emanuele Cacci, Giuseppe Lupo, Rodolfo Negri

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

4 authors.

Elena Di NisioDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.

Emanuele CacciDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.

Giuseppe LupoDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.

Rodolfo NegriDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy. Rodolfo.negri@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present an experimental strategy to dissect the effects of simulated microgravity on the interaction between cells and extracellular matrix. The protocol encompasses morphological and transcriptomic analyses on human neural progenitor cells (hNSPCs) cultured in flasks coated with poly-L-ornithine and laminin matrix at low density and subjected to microgravity simulation. High-density cultures subjected to microgravity or grown under normal gravity without a matrix are also analyzed as controls. The experimental approach could be adapted to different cell types by changing the extracellular matrix composition and the culture medium accordingly.

Indexed as

Cell AdhesionCell CommunicationExtracellular MatrixNeural Stem CellsWeightlessnessCell Culture TechniquesCells, CulturedHumansLamininWeightlessness SimulationLamininExtracellular matrixFocal adhesionHuman neural stem progenitor cellsLamininMicrogravitySpace conditions

Identifiers

PMID42151679

DOI10.1016/j.ejcb.2023.151330

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.