Evidence map›Paper›PMID 42153643›Full record

ArticlemSystems2026

CAZyme fold architecture is conserved between disparate environments despite extreme sequence divergence.

Oliyad Jeilu, Addis Simachew, Erica M Hartmann, Erik Alexandersson, Eva Johansson

Abstract read
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Oliyad JeiluDepartment of Plant Breeding, Swedish University of Agricultural Sciences, Lomma, Sweden.ORCID 0000-0002-3484-6552
Addis SimachewBiotechnology Research Centre, Institute of Advanced Science and Technology, Addis Ababa University, Addis Ababa, Ethiopia.
Erica M HartmannDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0002-0966-2014
Erik AlexanderssonDepartment of Plant Breeding, Swedish University of Agricultural Sciences, Lomma, Sweden.
Eva JohanssonDepartment of Plant Breeding, Swedish University of Agricultural Sciences, Lomma, Sweden.

Funding

Nilsson-Ehle Endowments 2021-09-28Svenska Forskningsrådet Formas 2019-01234
6 · The paper itself

Abstract

Microbial carbohydrate-active enzymes (CAZymes) underpin carbon cycling across Earth's ecosystems; however, how contrasting environments shape CAZyme diversity and structural conservation remains poorly understood. Here, we applied shotgun metagenomics to compare the carbohydrate-degradation potential of two functionally prolific but physicochemically opposed ecosystems: the alkaline-saline soda lakes of the East African Rift Valley and the anaerobic ruminant gut. From 34 metagenomes (12 soda lake and 22 rumen), we recovered 371 quality-filtered metagenome-assembled genomes, of which 84% of soda lake and 52% of rumen MAGs represented novel species. Rumen communities, dominated by

Indexed as

BacteriaGlycoside HydrolasesAnimalsLakesMetagenomeMetagenomicsPhylogenyProtein FoldingRumenGlycoside Hydrolasesbiogeochemical cyclescarbon cyclingCAZymesMAGsmicrobial diversityrumen microbiomeshotgun metagenomicssoda lakes

Identifiers

PMID42153643
PMCPMC13288935

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.