Evidence map›Paper›PMID 42154192›Full record

ArticleCell regeneration (London, England)2026

Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery.

Julia M Ferrick, Xinan Meng, Emily Morgan, Anthony Kalvi, Zhen Li, Chaoqun Li, Chao-Yuan Chang, Suhong Xu, Yi-Nan Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell regeneration (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julia M FerrickDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Xinan MengDepartment of Neurology, Center for Membrane Receptor and Brain Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, Zhejiang, China.
Emily MorganDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Anthony KalviDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Zhen LiDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052, Ghent, Belgium.
Chaoqun LiDepartment of Urology, Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Chao-Yuan ChangDepartment of Urology, Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Suhong XuCenter for Stem Cell and Regenerative Medicine and Department of Burn and Wound Repair of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China.
Yi-Nan GongDepartment of Urology, Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX, 77030, USA. ygong@houstonmethodist.org.ORCID http://orcid.org/0000-0002-3643-4682

Funding

Necrotic survivors and plasma membrane integrity signalingDP2GM146320 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GONG, YI-NAN · 2021 to 2024
$2.3M
Division of Cancer Epidemiology and Genetics, National Cancer Institute P30CA047904NIGMS NIH HHS DP2GM146320
6 · The paper itself

Abstract

Cells can recover from sub-lethal necrosis by repairing plasma-membrane (PM) rupture through the ESCRT-III machinery, but how this process is regulated remains unknown. Here, we identify Toll-interacting protein (Tollip) as a conserved negative regulator for ESCRT-III-mediated PM repair. Quantitative proteomics revealed the enrichment of Tollip at damaged PM. Additionally, microscopy assays in mammalian cells and C. elegans confirmed the recruitment of Tollip to PM injury sites. Tollip deficiency augmented ESCRT-III assembly, improved long-term cell survival after sub-lethal PM damage, and enhanced PM repair, whereas Tollip overexpression suppressed these processes. Tollip translocation occurred independently of Ca

Indexed as

Cell recoveryESCRT-IIINecroptosisPlasma membrane damagePlasma membrane integrity pathwayPlasma membrane repairProgrammed cell deathTollip

Identifiers

PMID42154192
PMCPMC13187079

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.