ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Use of DXA-based software to identify astronauts at risk for persisting spaceflight-induced bone loss.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dual-energy X-ray absorptiometry (DXA) alone is not ideal for fracture risk assessment given its two-dimensional nature. We evaluated the 3D-Shaper software for its potential to detect an unappreciated hip trabecular bone loss in astronauts. DXA-based 3D-Shaper software showed promising results as a screening tool while minimizing radiation exposure.
introductionProlonged spaceflight results in bone loss, as assessed by DXA performed before and after long-duration missions. Hip trabecular loss, detected by QCT but not DXA, persists in some astronauts for up to 2 years after 6-month missions. Since QCT increases radiation exposure, we evaluated a DXA software (3D-Shaper) as a screening method to identify astronauts in whom inadequate recovery of hip trabecular bone would be likely confirmed with QCT.
methodsHip data from 23 ISS astronauts (19 M/4F) with pre- and postflight QCT and DXA were analyzed. These scans were obtained pre-flight (within 4 months of launch), immediately post-flight (within 22 days of return), and 1-year post-flight (within 11-14 months). Left total hip data by DXA, QCT, and 3D-Shaper were expressed as percent change from pre-flight and evaluated by repeated measures ANOVA. A regression analysis of 1-year post-flight data compared the abilities of DXA (total hip areal BMD [aBMD]) and 3D-Shaper (trabecular volumetric BMD [Trab vBMD]) to predict persisting trabecular bone deficits as determined by QCT.
resultsImmediate postflight mean (SD) total hip aBMD was reduced by 3.9 (2.4)% with greater loss (p < 0.001) demonstrated by QCT and Shaper: 9.0 (7.2)% and 6.8 (4.5%), respectively. At 1-year post-flight, compared with QCT Trab vBMD change, R
conclusion3D-Shaper software predicts QCT-detected trabecular bone loss better than DXA and has the potential to serve as a screening tool for QCT-detection of trabecular bone loss.
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