ArticleThe Journal of cell biology2026
Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis.
Article in The Journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Astrocytes are essential for neuronal homeostasis, and synaptic modulation and development. While astrocytes exhibit distinct Ca2+ signaling patterns, decoding their physiological roles remains challenging because conventional approaches generate nonphysiological, spatially imprecise Ca2+ surges that obscure endogenous signals. Here, we developed a tunable light-based tool to modulate astrocytic Ca2+ activity, mimicking localized spikes and global waves elicited by graded glutamate through endogenous mGluR-Gq-IP3R signaling. IP3R triple knockout abolished light-evoked Ca2+ elevations, indicating elevated Ca2+ requires ER-IP3Rs. Using this modulation platform, we found that local Ca2+ spikes enhance organelle entry into astrocytic processes, whereas global Ca2+ waves arrest organelle movement. FKBP-FRB motor recruitment assays showed that global Ca2+ elevations acutely suppress motor-driven transport when cargo adaptors are bypassed. Combining our method with astrocyte process outgrowth analysis showed that Ca2+-dependent distal organelle accumulation promotes process elongation. Together, this light-based strategy provides a versatile platform for eliciting endogenous-like astrocytic Ca2+ patterns and reveals how distinct Ca2+ patterns differentially control organelle dynamics and astrocytic structural remodeling.
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