Evidence map›Paper›PMID 42156453›Full record

ArticleScientific reports2026

High glucose levels sensitize neuron-like cells to damage induced by oxidative and neurotoxic agents.

Jéssica Ellen Barbosa de Freitas Lima, Natália Chermont Dos Santos Moreira, Larissa de Oliveira Piassi, Renata Melo Dos Santos Ono, Elza Tiemi Sakamoto-Hojo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jéssica Ellen Barbosa de Freitas LimaDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID http://orcid.org/0000-0002-1522-7166
Natália Chermont Dos Santos MoreiraDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID http://orcid.org/0000-0003-1899-2733
Larissa de Oliveira PiassiDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID http://orcid.org/0000-0002-2063-3951
Renata Melo Dos Santos OnoDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID http://orcid.org/0000-0002-3363-2253
Elza Tiemi Sakamoto-HojoDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil. etshojo@usp.br.ORCID http://orcid.org/0000-0002-1383-3314

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 142223/2019-0Conselho Nacional de Desenvolvimento Científico e Tecnológico Proc. 309854/2017-2 and 311533/2021-3Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance code 001Fundação de Amparo à Pesquisa do Estado de São Paulo Proc. 2017/15123-1 and 2018/21709-1
6 · The paper itself

Abstract

Type 2 diabetes has been associated with cognitive decline and an increased risk of neurodegenerative diseases, although the cellular mechanisms underlying this relationship remain unclear. We investigated whether high-glucose exposure induces neuronal damage and increases susceptibility to secondary oxidative and neurotoxic insults in vitro. SH-SY5Y cells were differentiated into neuron-like cells and exposed to increasing glucose concentrations. Based on the viability results, cells exposed to high glucose (HG; 100 mM, 120 h) were further analyzed and challenged with hydrogen peroxide (H

Indexed as

GlucoseNeuronsNeurotoxinsOxidative StressApoptosisCell DifferentiationCell Line, TumorCell SurvivalDNA DamageHumansHydrogen PeroxideMitochondriaOkadaic AcidSuperoxidesGlucoseHydrogen PeroxideNeurotoxinsOkadaic AcidSuperoxidesDNA damageHyperglycemiaMitochondrial dysfunctionNeuronal cell deathOxidative stress

Identifiers

PMID42156453
PMCPMC13388942

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.