ArticleMolecular psychiatry2026
Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.
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Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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Who cites it
2 citing papers in PubMed.
- Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Longitudinal Trajectories of Cortical Folding in Schizophrenia Spectrum Disorders: A 13-Year Follow-Up Study.Schizophrenia bulletin · 2026Article
Corrections and comments
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Authors and funding
44 authors.
Stener NerlandDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway. stener.nerland@medisin.uio.no.ORCID http://orcid.org/0000-0001-8771-8856
Claudia BarthDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-6544-0945
Kjetil Nordbø JørgensenDivision of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-5751-4809
Laura A WortingerDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0003-2721-3172
Josefina Castro-FornielesDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM. Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0632-2687
Covadonga M Díaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, Madrid, Spain.ORCID http://orcid.org/0000-0001-8538-3175
Joost JanssenDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, Madrid, Spain.ORCID http://orcid.org/0000-0001-7613-2067
Celso ArangoHospital Universitario La Paz, IdiPAZ, School of Medicine, Universidad Autónoma de Madrid, CIBERSAM, Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Gisela SugranyesDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2545-7862
Inmaculada BaezaDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM. Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Spain.
Fabrizio PirasLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0003-3566-5494
Nerisa BanajLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-6317-8549
Federica PirasLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-9546-7038
Simone EliaLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0009-0003-5790-748X
Daniela VecchioLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0001-8428-7376
Mathias LundbergDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Hannes BohmanDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Bjørn Rishovd RundDepartment of Psychology, University of Oslo, Oslo, Norway.
Elena de la SernaDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clínic of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Adriana ForteaInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0003-3681-0841
Christian K TamnesDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-9191-6764
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-8644-956X
Runar E SmelrorDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Dimitrios AndreouDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Erik G JönssonDivision of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Matthew J KemptonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.ORCID http://orcid.org/0000-0003-3541-9947
Shuqing SiDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.ORCID http://orcid.org/0009-0006-6095-254X
Marinos Kyriakopoulos1st Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-4594-2646
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-8516-923X
Kristen LauletteDepartment of Psychology, UCLA, Los Angeles, California, USA.
Saül Pascual-DiazMagnetic Resonance Imaging Core Facility, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.
Anne-Kathrin J FettDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0282-273X
Katherine H KarlsgodtDepartment of Psychology, UCLA, Los Angeles, California, USA.
Lydia KrabbendamDepartment of Clinical, Neuro, and Developmental Psychology, Institute for Brain and Behavior Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Peter KochunovDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center Houston, Houston, TX, USA.
Sophia I ThomopoulosImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0002-0046-4070
Neda JahanshadImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Anthony JamesDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2742-8328
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID http://orcid.org/0000-0002-3210-6470
Anne M MyhreDivision of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Nils Eiel SteenDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-6442-1179
Ole A AndreassenDivision of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0002-4720-8867
Ingrid AgartzDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Funding
STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YEE-BRADBURY, CINDY M. · 2003 to 2014
$18.6M1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MENIGMA Bipolar Initiative: A Global Study of Imaging Genomics & Clinical OutcomesR01MH129742 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher Ching, PAUL M THOMPSON · 2022 to 2026
$3.0MGlobal studies into the Genetic Architecture of the Brain's White Matter Network through Harmonized and Coordinated Analyses in the ENIGMA-ConsortiumR01MH134004 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Neda Jahanshad · 2023 to 2026
$2.6MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MA global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5MHybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593kNIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIH HHS S10 OD023696NIMH NIH HHS P50 MH066286NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH129742NIMH NIH HHS R01 MH134004NIMH NIH HHS U01 MH081902Norges Forskningsråd (Research Council of Norway) 223273, 274359, 2137000, 250358, 288083, 323951
Abstract
Cortical brain morphology in early-onset psychosis (EOP; age of onset <19 years) is poorly understood, partly due to recruitment constraints linked to its low incidence. We pooled T1-weighted magnetic resonance imaging (MRI) data from 387 adolescents with EOP (mean age=16.1 ± 1.5; 49.6% female) and 338 healthy controls (CTR; mean age=15.8 ± 1.9, 54.4% female) from nine research sites worldwide. Using harmonized processing protocols, we extracted cortical brain metrics from 34 bilateral regions. Univariate regression analyses revealed widespread lower bilateral cortical thickness (left/right hemisphere: d = -0.36/-0.31), surface area (left/right: d = -0.42/-0.41), cortical volume (left/right: d = -0.58/-0.56), and Local Gyrification Index (LGI; left/right: d = -0.39/-0.52) in EOP relative to CTR. Diagnostic subgroup analyses showed broader and more pronounced case-control differences in early-onset schizophrenia for area, volume, and LGI. We found no associations with antipsychotic medication use, illness duration, age of onset, or positive symptoms. Negative symptoms were related to smaller left lingual volume (partial r = -0.21; p
Indexed as
Cerebral CortexPsychotic DisordersAdolescentAge of OnsetBrainFemaleHumansMagnetic Resonance ImagingMaleSchizophrenia
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