Evidence map›Paper›PMID 42157093›Full record

ArticleThe journal of headache and pain2026

Abnormal structural connectivity-functional connectivity coupling beyond the cortex in patients with chronic migraine.

Yan Li, Yixuan Hu, Chenyu Dai, Fangwang Fu, Yungang Cao, Keyang Chen, Jinming Cheng, Xiaozheng Liu

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Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Yan Li *Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Yixuan Hu *Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Chenyu DaiDepartment of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Fangwang FuDepartment of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Yungang CaoDepartment of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Keyang ChenDepartment of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Jinming ChengDepartment of Neurology of The Hebei General Hospital, Shijiazhuang, Hebei, 050050, China.
Xiaozheng LiuDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. lxz_2088@hotmail.com.

Funding

The Key Project of Medical Science Research of Hebei Province 20200002
6 · The paper itself

Abstract

backgroundStudies have shown that patients with chronic migraine exhibit abnormalities in structural and functional brain networks. However, the underlying brain mechanisms that govern structural-to-functional connectivity coupling in this population remain unclear.

methodsMultimodal functional MRI data were collected from 36 patients with chronic migraine without aura, 94 patients with episodic migraine without aura and 51 healthy controls. Spearman's correlation analysis was used to calculate SC-FC coupling. The Kruskal-Wallis test was used to compare differences in SC-FC coupling between the three groups. We also performed a correlation analysis to investigate the associations between SC-FC coupling and clinical variables.

resultsCompared with the healthy control group, patients with episodic migraine exhibited abnormal SC-FC coupling in the right rolandic operculum, left lingual gyrus, left pallidum, and vermis 7. In contrast, patients with chronic migraine exhibited abnormal SC-FC coupling in the left cerebellum 3, vermis 7, and pulvinar nucleus of the thalamus. Patients with chronic migraine exhibited abnormal SC-FC coupling in the left pulvinar nucleus of the thalamus compared with patients with episodic migraine. SC-FC coupling in the left cerebellum 3 of patients with chronic migraine was significantly associated with disability scores (r = -0.3731, p = 0.0250).

conclusionOur study identified SC-FC coupling alterations associated with chronic migraine. This suggests that abnormalities in SC-FC coupling in subcortical nuclei and the cerebellum may represent underlying mechanisms of chronic migraine.

Indexed as

BrainCerebral CortexMigraine DisordersAdultBrain MappingChronic DiseaseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysYoung AdultChronic migraineMultimodal functional magnetic resonance imagingStructural connectivity-functional connectivity coupling

Identifiers

PMID42157093
PMCPMC13366957

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LicenceCC BY-NC-ND
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