Evidence map›Paper›PMID 42157827›Full record

ArticleACS medicinal chemistry letters2026

Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na

Clemens Dialer, Sebastian Krüger, Markus Wagener, Marcel Mülbaier, Sebastian Peil, Mauro Marigo, Silke Hagendorf, Lishuang Cao, Cesar Ramirez Molina, Paul Morgan and 14 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Clemens DialerDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.ORCID https://orcid.org/0000-0002-5659-2776
Sebastian KrügerDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Markus WagenerDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.ORCID https://orcid.org/0000-0002-6708-5251
Marcel MülbaierDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Sebastian PeilDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Mauro MarigoGrünenthal Group, HQ, Zieglerstr. 6, 52078 Aachen, Germany.
Silke HagendorfDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Lishuang CaoDrug Discovery Engine, Grunenthal Ltd, Saint Cloud Way, Maidenhead, Berkshire SL6 8BN, United Kingdom.
Cesar Ramirez MolinaDrug Discovery Engine, Grunenthal Ltd, Saint Cloud Way, Maidenhead, Berkshire SL6 8BN, United Kingdom.
Paul MorganDrug Discovery Engine, Grunenthal Ltd, Saint Cloud Way, Maidenhead, Berkshire SL6 8BN, United Kingdom.
Clint YoungCambridge Innovation Center, GRT Therapeutics, Inc., 11th Floor, 1 Broadway, Cambridge, Massachusetts 02142, United States.
Lyn Rosenbrier RibeiroDrug Discovery Engine, Grunenthal Ltd, Saint Cloud Way, Maidenhead, Berkshire SL6 8BN, United Kingdom.
Inna SlynkoDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Stefanie RitterDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Monica GubermanDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Manuela HassDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Sascha KloskyDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Uta la TendresseDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Carsten GussmannDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Sven KühnertDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Stefanie PetersDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Sara Reichardt-OckenfeldDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Hannah DepmeierDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.
Florian JakobDrug Discovery Engine, Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibitors of voltage-gated sodium channel 1.8 (Na

Indexed as

NaV1.8 inhibitornonopioid analgesicsSCN10Aselective sodium channel blockerurea

Identifiers

PMID42157827
PMCPMC13181495

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.