ArticleFrontiers in nutrition2026
Dietary protein intake, inflammatory biomarkers, genetic susceptibility, and the incidence of sarcopenia: a prospective population-based study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia elevates risks of falls, hospitalization, and mortality in older adults. Despite protein's importance for muscle maintenance, evidence on its overall and source-specific role in sarcopenia development remains inconclusive, particularly regarding interactions with inflammation and genetic factors. Methods: We analyzed data from 37,870 participants in the UK Biobank. Cox proportional hazard models were used to evaluate the association between dietary protein intake and incident sarcopenia. Mediation analyses were conducted to assess whether inflammatory biomarkers mediate the dietary protein intake-sarcopenia association. A polygenic risk score (MetaPRS) for sarcopenia was constructed to explore the joint and interactive effects of dietary protein intake and genetic susceptibility on sarcopenia risk. Results: Higher dietary plant protein intake, but not total or animal protein, was modestly associated with a lower incidence of sarcopenia. Specifically, individuals in the highest intake quartile had a 25% lower risk than those in the lowest (HR = 0.75, 95%CI = 0.58-0.98) in the fully-adjusted model. Mediation analysis suggested that CRP, WBC count, monocyte count, and platelet count to explain 9.9% (95%CI = 4.8-41.5%) of the association, indicating that inflammatory biomarkers may partly contribute to this association. Conclusion: Higher dietary plant protein intake is modestly associated with a lower incidence of sarcopenia, and inflammatory biomarkers may partly contribute to this association.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.