ArticleTranslational pediatrics2026
Clinical characteristics and nutritional profiles of children with different irritable bowel syndrome subtypes: a retrospective hospital-based study.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Irritable bowel syndrome (IBS) is a common disorder of gut‑brain interaction (DGBI) in children, but data on its clinical heterogeneity and nutritional profiles across different IBS subtypes remain limited. This study aimed to characterize the clinical features of IBS subtypes and assess variations in nutritional status across subtypes and sexes in hospitalized children. Methods: Children hospitalized with an initial diagnosis of IBS at the Children's Hospital, Zhejiang University School of Medicine (January 2020 to October 2025) were enrolled. Demographic and clinical data regarding nutritional status were obtained. Results: Among 478 children with IBS (mean age, 12.29±2.19 years; 57.3% boys), diarrhea-predominant IBS (IBS-D) was the most common subtype (n=296, 61.9%), with a higher proportion of boys (66.6%). Sleep disturbances and symptom aggravation by cold/irritant foods varied by subtypes, with constipation-predominant IBS (IBS-C) being more likely to have sleep issues (P<0.008). Nutritional assessment showed higher height-for-age Z-scores (HAZs) and body mass index-for-age Z-scores (BAZs) in IBS-D than in IBS-C (P=0.003 and P=0.002, respectively), and hemoglobin levels also varied significantly across subtypes (F=18.13, P<0.001). Based on BAZ, 112 children were found with malnutrition, and 74 with obesity. Children with malnutrition more frequently exhibited selective eating behaviors (19.6% Conclusions: IBS-D predominated in hospitalized children, particularly in boys, and nutritional status differed across IBS subtypes and between sexes. These findings highlight the importance of comprehensive evaluation of nutritional status, psychological health, and lifestyle factors and support the need for individualized and multidisciplinary management strategies for children with IBS.
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