Evidence map›Paper›PMID 42159017›Full record

ArticleAllergy2026

Keratinocyte Priming by Staphylococcus aureus Reduces HSV-1 Susceptibility.

Phila Cara Baumann, Rebecca Pospich, Katinka Döhner, Ilona Klug, Julio Cesar Villalvazo Guerrero, Jan Hartmann, Inken Harder, Wolfgang Lieb, Barbara Kind, Andreas Kleinheinz and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Phila Cara BaumannDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0009-0002-1909-1865
Rebecca PospichDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0001-7920-3879
Katinka DöhnerDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-8222-3085
Ilona KlugDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0009-0005-4754-3576
Julio Cesar Villalvazo GuerreroInstitute of Virology, Hannover Medical School, Hannover, Germany.
Jan HartmannDepartment of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Inken HarderDepartment of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Wolfgang LiebInstitute of Epidemiology, Kiel University, Kiel, Germany.
Barbara KindCenter for Evidence-Based Health Care (ZEGV), Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.ORCID https://orcid.org/0009-0002-5254-6411
Andreas KleinheinzClinics for Dermatology, Elbe Klinikum Buxtehude, Buxtehude, Germany.
Susanne AbrahamCenter for Evidence-Based Health Care (ZEGV), Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0001-7457-6481
Matthias AugustinInstitute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-4026-8728
Elke WeisshaarOccupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-7016-0224
Jochen SchmittCenter for Evidence-Based Health Care (ZEGV), Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0003-0264-0960
Stephan WeidingerInstitute of Epidemiology, Kiel University, Kiel, Germany.ORCID https://orcid.org/0000-0003-3944-252X
Beate SodeikInstitute of Virology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0003-4650-3036
Thomas WerfelDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Lennart M RoesnerDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0001-6651-0458
Stephan TraidlDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0003-4806-599X
TREATgermany Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals with atopic dermatitis (AD) are at increased risk for skin infections, including eczema herpeticum (EH), a severe condition caused by herpes simplex virus type 1 (HSV-1). While AD skin is often colonized by Staphylococcus aureus (S. aureus), its role in EH susceptibility remains unclear. Here we aim to investigate differences in the skin microbiome of AD patients with (ADEH

methods16S microbiome sequencing was performed on skin samples from ADEH

resultsADEH

conclusionPre-incubation with S. aureus set basal keratinocytes into an alarmed state, restricting HSV-1 infection presumably via downregulation of receptors important for viral entry and activation of antiviral pathways.

Indexed as

Herpes SimplexHerpesvirus 1, HumanKeratinocytesStaphylococcus aureusCytokinesDermatitis, AtopicDisease SusceptibilityFemaleHumansKaposi Varicelliform EruptionSkin MicrobiomeCytokinesatopic dermatitiseczema herpeticumherpes simplex virusskin microbiotaStaphylococcus sppTh2 cytokines

Identifiers

PMID42159017
PMCPMC13466154

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.