Evidence map›Paper›PMID 42159028›Full record

ArticleGenetics research2026

Research Hotspots and Emerging Trends in Osteoporosis Epigenetics.

Maobin Zhou, Honglei Xiao, Ang Li, Hongze Chang, Xiaolong Yang, Feng Cai, Xiaodong Liu

Abstract readEvidence Synthesis
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maobin ZhouDepartment of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China, tongji.edu.cn.
Honglei XiaoDepartment of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China, tongji.edu.cn.
Ang LiDepartment of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China, tongji.edu.cn.
Hongze ChangDepartment of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China, tongji.edu.cn.
Xiaolong YangDepartment of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China, tongji.edu.cn.
Feng CaiDepartment of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China, tongji.edu.cn.ORCID 0009-0006-9923-4326
Xiaodong LiuDepartment of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China, tongji.edu.cn.ORCID 0000-0001-8572-3643

Funding

Natural Science Foundation of Shanghai Municipality 25ZR1401326Shanghai Healthcare System Key Discipline Construction Program 2024ZDXK0041Shanghai Rising-Star Program 23YF1441400Shanghai Yangpu District Science and Technology Commission and Health Commission Program YPM202302
6 · The paper itself

Abstract

backgroundOsteoporosis (OP) and its associated complications have emerged as critical public health challenges worldwide, primarily due to the high rates of disability and mortality they cause. In terms of its complex pathogenesis, epigenetic mechanisms play significant roles. Against this backdrop, this study aims to clarify the current research trends and hotspots in OP.

methodsLiterature was retrieved from the "Web of Science," "PubMed," and "Scopus." Subsequently, publication counts, country distribution, regional collaborations, and keyword analyses were conducted by using the "Bibliometrix" and "ggplot2" packages in R Studio. For visualization analysis, institutional cooperation and keyword relationships were examined using "CiteSpace" and "VOSviewer."

resultsA total of 464 publications were included in this analysis. The five most frequently cited keywords were "postmenopausal osteoporosis (PMOP)," "expression," "mesenchymal stem-cells (MSCs)," "osteogenic differentiation," and "differentiation." Keyword co-occurrence analysis further identified "expression," "PMOP," and "MSCs" as predominant research themes. Moving forward, the findings suggest that future research will focus on elucidating the role of miRNAs in the epigenetic mechanisms of OP and identifying potential therapeutic targets. Regarding global collaboration, China led in international partnerships, particularly with the United States.

conclusionEpigenetic mechanisms constitute a core regulatory factor in OP, serving as the critical link between genetic predisposition and environmental influences. Emerging research emphasizes the combined analysis of epigenetics and metabolomics, artificial intelligence (AI)-based prediction of epigenetic regulatory networks, and gene editing therapies targeting epigenetic factors. Furthermore, therapeutic strategies-including gene therapy, stem cell-based interventions, and small-molecule targeted compounds-represent pivotal future directions for OP therapeutics.

Indexed as

Epigenesis, GeneticOsteoporosisAnimalsEpigenomicsFemaleHumansMesenchymal Stem CellsMicroRNAsMicroRNAsartificial intelligenceepigeneticsestrogenexpressionmesenchymal stem cellsosteoporosis

Identifiers

PMID42159028
PMCPMC13189465

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.