Evidence map›Paper›PMID 42159291›Full record

ArticleAnnals of medicine2026

Correlation of foot process effacement with clinicopathological features and short-term prognosis in IgA nephropathy.

Yu Wang, Yang Yang, Xiaoli Wen, Lu Yi, Fang Zeng, Baoqin Zhou, Lijuan Wang, Wenjun Yan, Daijin Ren, Shizhang Xu and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Yu WangDepartment of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yang YangDepartment of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xiaoli WenDepartment of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Lu YiDepartment of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Fang ZengDepartment of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Baoqin ZhouDepartment of Nephrology, Xinyu People's Hospital, Xinyu, China.
Lijuan WangDepartment of Nephrology, Shangrao People's Hospital, Shangrao, China.
Wenjun YanDepartment of Nephrology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, PR China.
Daijin RenDepartment of Health Management Center, Jiangxi Provincial People's Hospital, Nanchang, PR China.
Shizhang XuDepartment of Nephrology, Yichun People's Hospital, Yichun, China.
Yebei LiDepartment of Health Management Center, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Dehui LiuDepartment of Nephrology, The Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, P. R. China.
Kaiping LuoDepartment of Nephrology, The Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, P. R. China.
Hong JiangKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, PR China.
Gaosi XuDepartment of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare clinicopathological characteristics and short-term renal outcomes of IgA nephropathy (IgAN) patients with varying degrees of foot process effacement (FPE).

methodsThis multicenter retrospective study evaluated 1,001 biopsy-proven IgAN patients grouped by FPE severity (mild, moderate, severe). Regression models identified factors associated with different FPE degrees. Short-term outcomes in a 1-year follow-up subset were analyzed using overlap weighting, Cox regression, and Kaplan-Meier analysis.

resultsThe cohort comprised 38.8% mild, 49.6% moderate, and 11.6% severe FPE cases. Greater FPE severity corresponded with elevated blood pressure, proteinuria, and anemia, alongside decreased estimated glomerular filtration rate (eGFR) and albumin levels. Pathologically, worsening FPE correlated with advanced mesangial hyperplasia and tubulointerstitial damage. Severe FPE was distinctively associated with higher serum phosphorus, endocapillary hypercellularity (E1), and progressive interstitial fibrosis (T). Among 486 followed patients, complete remission rates were significantly lower in the severe FPE group than in the mild group (HR = 0.475,

conclusionsThe degree of FPE in IgAN was significantly positively correlated with proteinuria, hypoalbuminemia, eGFR decline, mesangial hypercellularity, and tubular atrophy/interstitial fibrosis. Severe FPE is an independent risk factor influencing short-term renal outcomes in IgAN patients.

Indexed as

Glomerulonephritis, IGAPodocytesAdultBiopsyDisease ProgressionFemaleGlomerular Filtration RateHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisProteinuriaRetrospective StudiesSeverity of Illness Indexfoot process effacementIgA nephropathypodocyte

Identifiers

PMID42159291
PMCPMC13195703

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.