ArticlemBio2026
Urosepsis by multidrug-resistant
Hans Carolus, Vladislav Biriukov, Jolien Vreys, Celia Lobo Romero, Juan Paulo Herrera Avila, Rudy Vergauwen, Dimitrios Sofras, Jana Nysten, Giel Vanreppelen, Lore Vinken and 5 more
Abstract readCase Reports
In one paragraphArticle in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Hans CarolusLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1507-3475 Vladislav BiriukovInstitute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona, Spain.
Jolien VreysLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, Leuven, Belgium.
Celia Lobo RomeroLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, Leuven, Belgium.
Juan Paulo Herrera AvilaDepartment of Infectious Diseases, Ziekenhuis Aan de Stroom (ZAS) Antwerpen, Antwerp, Belgium.
Rudy VergauwenLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, Leuven, Belgium.
Dimitrios SofrasLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-1767-0831 Giel VanreppelenLaboratory of Molecular Cell Biology, Department of Biology, KU Leuven, Leuven, Belgium.
Lore VinkenDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Basil Britto XavierDepartment of Infectious Diseases, Ziekenhuis Aan de Stroom (ZAS) Antwerpen, Antwerp, Belgium.
Toni GabaldónInstitute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0003-0019-1735 Katrien LagrouDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8668-1350 Reinout NaesensDepartment of Infectious Diseases, Ziekenhuis Aan de Stroom (ZAS) Antwerpen, Antwerp, Belgium.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The emergence of multidrug-resistant fungal pathogens from urinary tract infections (UTIs) poses a growing challenge in clinical settings. Here, we report a case of a complicated UTI caused by IMPORTANCE: Evolutionary theory states that fitness determines survival. In a drug-treatment environment, resistance increases fitness, but it often comes at a cost, such as slower growth or reduced stress tolerance. If these costs are too severe, they can undermine virulence, making resistance unlikely to persist. Our study challenges this assumption. We describe the first clinical case of
Indexed as
Antifungal AgentsCandida glabrataDrug Resistance, Multiple, FungalNitroquinolinesSepsisUrinary Tract InfectionsFungal ProteinsHumansLoss of Function MutationMicrobial Sensitivity TestsAntifungal AgentsFungal ProteinsNitroquinolinesnitroxolineamphotericin B resistanceantifungal resistanceCandida glabratacollateral sensitivityERG11ERG3fitness trade-offsmultidrug resistanceNakaseomyces glabratusnitroxolineurinary tract infectionurosepsis
Identifiers
PMID42159367
PMCPMC13251396
What Socratic holds
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LicenceCC BY
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