Evidence map›Paper›PMID 42159631›Full record

ArticleNeurochemical research2026

Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson's Disease Knockin Mice.

Hung-Li Wang, Shu-Yu Liu, Ching-Chi Chiu, Tu-Hsueh Yeh, Wan-Shia Chen, Tai-Ju Chiu, Yi-Chun Yeh, Pei-Rung Wu, Yi-Hsin Weng

Abstract read
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In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hung-Li WangDepartment of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Shu-Yu LiuDepartment of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Ching-Chi ChiuHealthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Tu-Hsueh YehDepartment of Neurology, Taipei Medical University Hospital, Taipei, Taiwan.
Wan-Shia ChenDepartment of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Tai-Ju ChiuGraduate Institute of Biomedical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Yi-Chun YehDepartment of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Pei-Rung WuDepartment of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Yi-Hsin WengDivision of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. yhweng2488@gmail.com.

Funding

National Science and Technology Council, Taiwan NSTC 110-2320-B-182-003-MY3
6 · The paper itself

Abstract

Heterozygous (G603R) LRP10 mutation causes autosomal dominant Parkinson's disease (PD). Heterozygous Lrp10

Indexed as

alpha-SynucleinDopaminergic NeuronsDown-RegulationLDL-Receptor Related ProteinsParkinson DiseaseRNA, MessengerSubstantia NigraAnimalsGene Knock-In TechniquesMiceMice, Inbred C57BLMice, Transgenicalpha-SynucleinLDL-Receptor Related ProteinsRNA, MessengerAutosomal dominant Parkinson’s disease(G603R) LRP10 mutationLrp10G603R/+ knockin mouseSubstantia nigra dopaminergic neuronsα-Synuclein mRNA

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.