Evidence map›Paper›PMID 42162421›Full record

ArticleNature2026

De novo design of quasisymmetric two-component protein cages.

Shunzhi Wang, Ying Xie, David Chmielewski, Connor Weidle, Tong Shu, Green Ahn, Ryan D Kibler, Cindy Hernandez, Wei Chen, David Camilo Duran and 14 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Shunzhi WangDepartment of Biochemistry, University of Washington, Seattle, WA, USA. shunzhi.wang@nyulangone.org.ORCID http://orcid.org/0000-0001-5033-7478
Ying XieInstitute for Systems Genetics, New York University Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9992-3504
David ChmielewskiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Connor WeidleDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9354-2276
Tong ShuInstitute for Systems Genetics, New York University Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6036-0057
Green AhnDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Ryan D KiblerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6984-9887
Cindy HernandezInstitute for Systems Genetics, New York University Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0009-0000-4925-6208
Wei ChenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5255-4166
David Camilo DuranInstitute for Systems Genetics, New York University Langone Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2565-6404
Ann CarrDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9473-2912
Sangmin LeeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1145-4708
Justin DecarreauDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5487-0499
Evans BrackenbroughDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Emily JoyceDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0007-3230-1341
Kejia WuDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4532-4290
Andrew J BorstDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4297-7824
Andrew FavorInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9977-2785
Buwei HuangInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Frank DiMaioDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7524-8938
Liam J HoltInstitute for Systems Genetics, New York University Langone Medical Center, New York, NY, USA.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal DementiaR01NS127186 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOLT, LIAM J, PHATNANI, HEMALI · 2021 to 2025
$8.2M
Cancer under pressure: Mechanisms of adaptation to compressive stressR37CA240765 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2025
$3.2M
Designed Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5M
Tools to probe the biophysical properties of cellsR01GM132447 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2022
$2.1M
Howard Hughes Medical InstituteNCI NIH HHS R37 CA240765NIA NIH HHS R01 AG063845NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM132447NINDS NIH HHS R01 NS127186
6 · The paper itself

Abstract

Quasisymmetric icosahedral viral capsids achieve larger sizes than possible with strictly symmetric icosahedra by tessellating pentagons and hexagons using a single subunit that adopts different conformations in symmetrically non-equivalent locations

Indexed as

Protein EngineeringAnimalsCapsidHumansModels, MolecularMolecular WeightProtein Multimerization

Identifiers

PMID42162421
PMCPMC13412984

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.