Evidence map›Paper›PMID 42163108›Full record

ArticleBMC genomics2026

Nutritional restriction during late gestation disrupts placental transcriptional programs related to metabolism, transport, and immune function in a sheep model.

Weibin Wu, Ye Xu, Pengpeng Liu, Yuting Yang, Huizhen Lu, Muhammad Ajwad Rahim, Baoyuan Li, Shuai Liu, Shengyong Mao, Jianbo Cheng and 4 more

Abstract read
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In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Weibin Wu *College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Ye Xu *College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Pengpeng Liu *College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Yuting YangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Huizhen LuBiotechnology Center, Anhui Agricultural University, Hefei, 230036, China.
Muhammad Ajwad RahimCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Baoyuan LiCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Shuai LiuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Shengyong MaoCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Jianbo ChengCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Xiaoling ZhouCollege of Animal Science and Technology, Tarim University, Alar, 843300, China.
Guishan XuCollege of Animal Science and Technology, Tarim University, Alar, 843300, China.
Mianqun ZhangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China. zhangmianqun@ahau.edu.cn.
Yanfeng XueCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China. xueyanfeng1990@163.com.

Funding

AAU Introduction of High-level Talent Funds RC392107Anhui Provincial Natural Science Foundation 2308085QC104Anhui Provincial Natural Science Foundation 2308085QC82Anhui Provincial Science and Technology Aid Project for Tibet, Xinjiang, and Qinghai 2025Key Laboratory of Utilization of Livestock and Forage Resources in Circum-Tarim Region (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs BSGJSYS202502National Key Research and Development Program of China 2022YFD1301102National Natural Science Foundation of China 32402767Natural Science Research Project of Anhui Province 2025AHGXZK40221
6 · The paper itself

Abstract

backgroundStudies on the effects of nutrition on the placenta mainly focus on early to middle pregnancy due to rapid fetal development during this period. In late gestation, although nutrient restriction has been linked to adverse fetal outcomes and altered uteroplacental physiology, the placental transcriptional programs that coordinate substrate transport, metabolic adaptation, and immune-related pathways under maternal undernutrition remain incompletely characterized, particularly in large-animal models. Therefore, this study aims to characterize transcriptional alterations associated with placental metabolism, nutrient transport, and immune regulation in response to nutritional restriction during late pregnancy.

resultsIn this study, late-gestation ewes were restricted to 30% feeding levels for 15 days to establish an undernourished sheep model. Results indicated that nutritional restriction during late pregnancy didn't affect placental weight and cotyledon number but reduced placental efficiency. Nutritional restriction lowered placental carbohydrate metabolism and altered amino acid metabolism, thereby increasing glucose and essential amino acid levels and decreasing non-essential amino acid levels in the umbilical cord blood (UCB). Nutritional restriction disrupted ubiquitination and the proteinase and suppressed transcription factors, collagen formation, cell adhesion and migration, and capillary genesis in the placenta from male fetuses. Placental complement pathways were inhibited by nutritional restriction, indicating the weakened immune function.

conclusionsThis study revealed that nutritional restriction affects placental function in many ways, subsequently influencing fetal growth and development, which provides a basis for future research on the fetal.

Indexed as

PlacentaTranscription, GeneticAnimalsBiological TransportFemaleMalePregnancySheepAmino acidImmune responseLipidMaterial metabolismNutritional restriction

Identifiers

PMID42163108
PMCPMC13390227

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.