ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- 2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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19 authors.
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Abstract
introductionWe examined the impact of mid-life metabolites on late-life Alzheimer's disease (AD) plasma biomarkers and whether these metabolites mediate air pollution effects.
methodsIn the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) cohort, we applied high-dimensional regression and meditation models, adjusting for observed and latent confounders, with replication in the Atherosclerosis Risk in Communities (ARIC) study. Exposures included mid-life fine particulate matter (PM
resultsIn the Heart SCORE study, seven lipid- and amnio acid-pathway metabolites measured in mid-life were significantly inversely associated with late-life p-tau181 levels (false discovery rate ≤ 15%) and showed a nominal inverse association with p-tau217 and 231 (P < 0.05). 2-aminobutyrate was associated with mid-life PM DISCUSSION: Mid-life metabolite profiles, particularly 2-aminobutyrate, may predict and mediate air pollution-related AD risk. HIGHLIGHTS: Seven mid-life metabolites were inversely linked to late-life plasma phosphorylated tau (p-tau)181. 2-aminobutyrate was tied to fine particulate matter (PM
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