Evidence map›Paper›PMID 42165587›Full record

ArticleApplied and environmental microbiology2026

Pathway and efflux engineering to utilize endogenous high isoprenoid flux in

Dattesh Bala Saranga, C K Pooja, Amrita Singh, M V Adarsh, N R Kiran, Chandan U Gowda, Poonam Kumari, Ankita, Aafreen Zehra, Pranav Murali Sharma and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dattesh Bala SarangaSynthetic Biology and Bacterial Functional Genomics Lab, CSIR-Central Institute of Medicinal and Aromatic Plants Research Centre, Bengaluru, India.
C K PoojaSynthetic Biology and Bacterial Functional Genomics Lab, CSIR-Central Institute of Medicinal and Aromatic Plants Research Centre, Bengaluru, India.
Amrita SinghSynthetic Biology and Bacterial Functional Genomics Lab, CSIR-Central Institute of Medicinal and Aromatic Plants Research Centre, Bengaluru, India.
M V AdarshSynthetic Biology and Bacterial Functional Genomics Lab, CSIR-Central Institute of Medicinal and Aromatic Plants Research Centre, Bengaluru, India.
N R KiranMolecular Plant Biology and Biotechnology Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, India.
Chandan U GowdaSynthetic Biology and Bacterial Functional Genomics Lab, CSIR-Central Institute of Medicinal and Aromatic Plants Research Centre, Bengaluru, India.
Poonam KumariSynthetic Biology Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
AnkitaSynthetic Biology Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Aafreen ZehraSynthetic Biology Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Pranav Murali SharmaAnalytical Chemistry and Phytochemistry Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, India.
Rudra Prakash MohantyAnalytical Chemistry and Phytochemistry Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, India.
V S PragadheeshAnalytical Chemistry and Phytochemistry Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, India.
Dinesh A NagegowdaMolecular Plant Biology and Biotechnology Lab, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, India.
Mukti N MishraSynthetic Biology and Bacterial Functional Genomics Lab, CSIR-Central Institute of Medicinal and Aromatic Plants Research Centre, Bengaluru, India.ORCID 0000-0001-6221-6403

Funding

CSIR-Aroma Mission HCP-007CSIR-CIMAP FTT FTT020501SERB, India CRG/2018/003748SERB, India CRG/2023/004398
6 · The paper itself

Abstract

Sesquiterpenes, mainly produced by plants as secondary metabolites, are synthesized from farnesyl pyrophosphate (FPP, an intermediate of the carotenoid biosynthesis pathway) by sesquiterpene synthases (STPSs). The ever-increasing commercial applications have increased the demand for several sesquiterpenes, and the limitations associated with their natural extraction and chemical synthesis have shifted the interest toward heterologous sesquiterpene production using engineered microbes. However, most of the engineered microbes lack the industrial potential yield. Since a high carotenoid yield reflects an equally high flux through FPP, we developed improved carotenoid-producing strains of

Indexed as

Azospirillum brasilenseMetabolic EngineeringSesquiterpenesTerpenesCarotenoidsMonocyclic SesquiterpenesPolyisoprenyl PhosphatesCarotenoidsfarnesyl pyrophosphatehumuleneMonocyclic SesquiterpenesPolyisoprenyl PhosphatesSesquiterpenesTerpenesvalenceneAzospirillum brasilensecarotenoidsmetabolic engineeringsesquiterpenes

Identifiers

PMID42165587
PMCPMC13274349

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.