Evidence map›Paper›PMID 42165639›Full record

ReviewCancer reports (Hoboken, N.J.)2026

Gut Microbiota: A Potential Role in Modulating Carcinogenesis and Response to Anti-Cancer Therapies.

Awgichew Shewasinad Yehualashet, Eleni Teklu Fersha, Berhan Begashaw Yikna, Kassahun Dires Ayenew

Abstract readReview
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Awgichew Shewasinad YehualashetDepartment of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.ORCID 0000-0002-8245-967X
Eleni Teklu FershaDepartment of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.
Berhan Begashaw YiknaDepartment of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.ORCID 0000-0001-7298-2865
Kassahun Dires AyenewDepartment of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.ORCID 0000-0001-7262-8663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effects of microbiota on cancer are not only limited to their role in oncogenesis, progression and response to anticancer therapies; the disease itself is also influenced by microbiota. In recent investigations, alterations in the gut bacterial community between cancer patients and healthy individuals have been reported. Outcomes targeted to gut microbiota composition, microbial metabolites, immune responses, and other pertinent measures are also aggregated and elaborated in this review. RECENT

findingsNumerous preclinical and clinical experiments have explored the use of gut microbiota as a new research avenue with encouraging outcomes in enhancing treatment efficacy and mitigating side effects related to treatment. The pathophysiology of cancer cells and modulation by microbiomes via many signaling pathways could be useful in determining the role of microbiota in developing novel therapeutic approaches and possible targets for cancer treatment.

conclusionThough different bacterial species can cause various clinical outcomes, more research is still required to identify more precise and profound underlying mechanisms in the relationship between gut microbiota and anticancer therapy. This could lead to improved patient outcomes overall and more focused clinical applications down the road.

Indexed as

Antineoplastic AgentsCarcinogenesisGastrointestinal MicrobiomeNeoplasmsAnimalsHumansAntineoplastic Agents

Identifiers

PMID42165639
PMCPMC13239962

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.