Evidence map›Paper›PMID 42166010›Full record

ArticleArchives of toxicology2026

Lentiviral-mediated expression of cytochrome P450 2D6 in HepaRG cells: new means for in vitro xenobiotic biotransformation and cellular response to chimeric viral mRNA.

Hugo Coppens-Exandier, Franz Mackanga, Thomas Darde, Corentin Bonhomme, Gaëlle Angenard, Patricia Leroyer, Catherine Ribault, Thomas Gicquel, Romain Pelletier, Flyuza Roshchina and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hugo Coppens-ExandierInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Franz MackangaInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Thomas DardeSciLicium, 10 rue de la Sauvaie, 35000, Rennes, France.
Corentin BonhommeSciLicium, 10 rue de la Sauvaie, 35000, Rennes, France.
Gaëlle AngenardInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Patricia LeroyerInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Catherine RibaultInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Thomas GicquelInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Romain PelletierInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Flyuza RoshchinaBiopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.
Estelle SchaeferBiopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.
Christophe ChesnéBiopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.
Agnès JaminBiopredic International, Parc d' Affaires de la Bretèche Bâtiment A4, 35760, Saint Grégoire, France.
Anne CorluInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France.
Pascal LoyerInstitut NuMeCan (Nutrition Metabolisms and Cancer), Inserm UMR-S 1317, INRAE UMR-A 1341, CHU Pontchaillou, 35033, Univ Rennes, F-35000, Rennes, France. pascal.loyer@univ-rennes.fr.ORCID 0000-0002-5656-2673

Funding

Association Nationale de la Recherche et de la Technologie CIFRE n° 221206A10Institut de la santé et de la recherche médicale Institut de la santé et de la recherche médicale
6 · The paper itself

Abstract

The human HepaRG

Indexed as

Cytochrome P-450 CYP2D6HepatocytesLentivirusRNA, MessengerXenobioticsBiotransformationCell LineHumansTramadolCytochrome P-450 CYP2D6RNA, MessengerTramadolXenobioticsCYP2D6HepaRG cellsLentiviral transductionNXF3PerhexilineTramadolWoodchuck hepatitis virus post-transcriptional regulatory element (WPRE)

Identifiers

PMID42166010

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.