Evidence map›Paper›PMID 42166242›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84.

Mausam Kalita, Renesmee C Kuo, Valentina Straniero, Samantha T Reyes, Mallesh Pandrala, Alessia Lanzini, Sara Marsango, Desiree D'Moore, Piper Mahn, Andrew Setiadi and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mausam Kalita *Department of Radiology, Stanford University, Stanford, CA 94305.ORCID 0000-0002-4847-2678
Renesmee C Kuo *Department of Radiology, Stanford University, Stanford, CA 94305.ORCID 0000-0002-9309-2914
Valentina StranieroDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy 20133.ORCID 0000-0002-5089-0879
Samantha T ReyesDepartment of Radiology, Stanford University, Stanford, CA 94305.
Mallesh PandralaDepartment of Radiology, Stanford University, Stanford, CA 94305.
Alessia LanziniDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy 20133.ORCID 0009-0009-0178-4541
Sara MarsangoCentre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom G12 8QQ.ORCID 0000-0002-0590-7942
Desiree D'MooreDepartment of Radiology, Stanford University, Stanford, CA 94305.ORCID 0009-0000-4698-4808
Piper MahnDepartment of Radiology, Stanford University, Stanford, CA 94305.
Andrew SetiadiDepartment of Radiology, Stanford University, Stanford, CA 94305.
Mira SundarDepartment of Radiology, Stanford University, Stanford, CA 94305.
Spencer MakDepartment of Radiology, Stanford University, Stanford, CA 94305.
Sydney NagyDepartment of Radiology, Stanford University, Stanford, CA 94305.ORCID 0000-0002-1837-8955
Israt S AlamDepartment of Radiology, Stanford University, Stanford, CA 94305.
Poorva JainDepartment of Radiology, Stanford University, Stanford, CA 94305.
Grace InayDepartment of Radiology, Stanford University, Stanford, CA 94305.
Rim MalekDepartment of Radiology, Stanford University, Stanford, CA 94305.
Allen F BrooksDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Corinne BeinatDepartment of Radiology, Stanford University, Stanford, CA 94305.ORCID 0000-0003-1718-3272
Ermanno ValotiDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy 20133.
Peter J H ScottDivision of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109.
Graeme MilliganCentre for Translational Pharmacology, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom G12 8QQ.ORCID 0000-0002-6946-3519
Michelle L JamesDepartment of Radiology, Stanford University, Stanford, CA 94305.ORCID 0000-0002-9934-7084

Funding

Development and assessment of new highly specific PET tracers for imaging innate immune activation in Alzheimer's diseaseF31AG094229 · NIA · STANFORD UNIVERSITY · PI Renesmee Chenting Kuo · 2026 to 2026
$50k
HHS | NIH | National Institute on Aging (NIA) F31AG094229NSF | NSF Graduate Research Fellowship Program (GRFP) DGE-2146755SU | Wu Tsai Neurosciences Institute, Stanford University (Wu Tsai Neurosciences Institute) N/AUKRI | Biotechnology and Biological Sciences Research Council (AFRC) APP72799
6 · The paper itself

Abstract

Innate immunity mediated by myeloid cells defends against infection and injury, but when chronically activated, it drives tissue damage and neurodegeneration. Molecular imaging with positron emission tomography (PET) enables noninvasive, real-time monitoring of such processes in vivo. However, most current neuroinflammation PET tracers lack specificity for activated myeloid cells. G protein-coupled receptor 84 (GPR84) is a promising biomarker that is selectively upregulated on activated microglia and macrophages. Here, we report the development and validation of two fluorine-18-labeled GPR84 tracers, [

Indexed as

InflammationMyeloid CellsNeuroinflammatory DiseasesPositron-Emission TomographyReceptors, G-Protein-CoupledAnimalsBrainFluorine RadioisotopesHumansLipopolysaccharidesMiceMicrogliaRadiopharmaceuticalsReceptors, GABABzrp protein, mouseFluorine-18Fluorine RadioisotopesLipopolysaccharidesRadiopharmaceuticalsReceptors, GABAReceptors, G-Protein-CoupledAlzheimer’s diseaseG protein–coupled receptor 84 (GPR84)innate immune activationneuroinflammationpositron emission tomography (PET)

Identifiers

PMID42166242
PMCPMC13214000

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.