Evidence map›Paper›PMID 42166798›Full record

ArticleACS nano2026

Force-Induced Ankle Opening Reveals Mechanical Stabilization of the Ankle of Human β-Cardiac Myosin.

Surya Pratap S Deopa, Kristen K Bjorkman, Devin T Edwards, Marc-André LeBlanc, Massimo Buvoli, Steven H Oakes, Brandon Dzuba, Anastasia Karabina, Leslie A Leinwand, Thomas T Perkins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Surya Pratap S DeopaJILA, National Institute of Standards and Technology and University of Colorado, Boulder, Colorado 80309, United States.
Kristen K BjorkmanDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Devin T EdwardsJILA, National Institute of Standards and Technology and University of Colorado, Boulder, Colorado 80309, United States.
Marc-André LeBlancJILA, National Institute of Standards and Technology and University of Colorado, Boulder, Colorado 80309, United States.ORCID 0000-0002-5520-7389
Massimo BuvoliDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Steven H OakesJILA, National Institute of Standards and Technology and University of Colorado, Boulder, Colorado 80309, United States.
Brandon DzubaJILA, National Institute of Standards and Technology and University of Colorado, Boulder, Colorado 80309, United States.
Anastasia KarabinaDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Leslie A LeinwandDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Thomas T PerkinsJILA, National Institute of Standards and Technology and University of Colorado, Boulder, Colorado 80309, United States.ORCID 0000-0003-4826-9490

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human β-cardiac myosin drives contraction in the heart. Extensive biophysical and single-molecule studies have quantified myosin's chemo-mechanical cycle, which generates ∼5 nm of displacement and 5-7 pN of force. Myosin's 9 nm-long, α-helical lever arm is rigidified by bound essential and regulatory light chains (ELC and RLC). Numerous pathogenic mutations and sequence-conservation patterns within the lever arm where the RLC binds (LA

Indexed as

Ventricular MyosinsBiomechanical PhenomenaHumansMicroscopy, Atomic ForceModels, MolecularProtein StabilityVentricular Myosinsatomic force microscopycoarse-grained simulationhypertrophic cardiomyopathymyosinregulatory light chainsingle-molecule force spectroscopy

Identifiers

PMID42166798
PMCPMC13255530

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.