Evidence map›Paper›PMID 42167103›Full record

ArticleJACC. Advances2026

Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants.

Shaun Khanna, Gurkeerat Mann, Sohaib Virk, Aditya Bhat, Sheran Vasanthakumar, Sarang Paleri, Andrew Lin, Lauren Houston, Damini Dey, Deepak L Bhatt and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shaun KhannaThe George Institute for Global Health, UNSW Sydney, New South Wales, Australia; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Gurkeerat MannDepartment of Cardiology, Westmead and Blacktown Hospital, Sydney, New South Wales, Australia.
Sohaib VirkUniversity of Melbourne, Parkville, Victoria, Australia.
Aditya BhatDepartment of Cardiology, Westmead and Blacktown Hospital, Sydney, New South Wales, Australia.
Sheran VasanthakumarBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Victorian Heart Institute, Victorian Heart Hospital, Clayton, Victoria, Australia.
Sarang PaleriBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Victorian Heart Institute, Victorian Heart Hospital, Clayton, Victoria, Australia.
Andrew LinBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Victorian Heart Institute, Victorian Heart Hospital, Clayton, Victoria, Australia.
Lauren HoustonThe George Institute for Global Health, UNSW Sydney, New South Wales, Australia.
Damini DeyCedars-Sinai Medical Center, Los Angeles, California, USA.
Deepak L BhattDepartment of Cardiology, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Clare ArnottThe George Institute for Global Health, UNSW Sydney, New South Wales, Australia; Department of Cardiology, St Vincent's Hospital, Darlinghurst, New South Wales, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Nitesh NerlekarBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Victorian Heart Institute, Victorian Heart Hospital, Clayton, Victoria, Australia. Electronic address: nitesh.nerlekar@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery calcium (CAC) is a robust marker of subclinical atherosclerosis and cardiovascular risk. Body mass index (BMI) may inadequately reflect central adiposity, which may be more strongly associated with CAC burden and progression.

objectivesThe objective of the study was to compare associations of BMI, waist circumference (WC), and waist-to-hip ratio (WHR) with CAC presence and progression in individuals without established cardiovascular disease.

methodsA systematic search of PubMed, MEDLINE, Embase, CINAHL, Scopus, and gray literature (January 2000-March 2025) identified studies reporting anthropometric measures by CAC status (CAC = 0 vs >0) or progression. Two reviewers applied Preferred Reporting Items for Systematic reviews and Meta-Analyses-based criteria. Standardized mean differences (SMDs) were pooled using random-effects models. Heterogeneity was assessed with I-squared statistic (I

resultsForty-nine studies were included (33 CAC presence; 16 progression) across 10 countries. For CAC presence (n = 43,490), WHR (SMD: 0.46; 95% CI: 0.35-0.56; I

conclusionsCentral adiposity measures (WHR and WC) show stronger associations with CAC presence and progression than BMI, supporting their use as markers of cardiovascular risk while highlighting limitations of BMI alone. (Anthropometrics and subclinical coronary artery calcification: a systematic review and meta-analysis; CRD420251083057).

Indexed as

body mass indexcoronary calcificationwaist circumferencewaist-to-hip ratio

Identifiers

PMID42167103
PMCPMC13199779

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.