ArticleNature communications2026
Insulin receptor
Brandon T Hubbard, Yumin Ma, Rafael C Gaspar, Traci E LaMoia, Dongyan Zhang, Mario Kahn, Sylvie Dufour, Ali Nasiri, Gerald I Shulman
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Yumin MaDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Rafael C GasparDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Traci E LaMoiaDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Dongyan ZhangDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Mario KahnDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Sylvie DufourDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Ali NasiriDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Funding
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · 1986 to 2025
$10.2MMedical Scientist Training ProgramT32GM136651 · YALE UNIVERSITY · 2025 to 2025
$2.3MYale Center for Metabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK134901 · YALE UNIVERSITY · 2025 to 2025
$763kMechanism of Renal Cortical Insulin ResistanceR01DK133143 · YALE UNIVERSITY · 2025 to 2025
$573kElucidating the pathophysiology and molecular mechanisms of renal insulin resistanceF30DK131846 · YALE UNIVERSITY · 2025 to 2025
$55kNovo Nordisk Fonden (Novo Nordisk Foundation) NNF25SA0106990U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) F30DK131846U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) F31DK12632U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK034989U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK134901U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK133143U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) RC2DK120534U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U2CDK134901U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM136651
6 · The paper itselfAbstract
Impaired suppression of endogenous glucose production (EGP) drives end-organ damage in insulin resistance and type 2 diabetes. Although the liver is traditionally thought to mediate dysregulated EGP, the role of the renal cortex is less understood. Here, we investigate if high-fat diet (HFD) induces renal cortical insulin resistance while assessing renal glucose production (RGP) and mitochondrial metabolism in male mice. HFD increases plasma membrane sn-1,2-DAGs, PKCε translocation, and Insulin Receptor Kinase (IRK)
Indexed as
GluconeogenesisGlycerolInsulin ResistanceKidney CortexReceptor, InsulinAnimalsDiet, High-FatGlucoseInsulinMaleMiceMice, Inbred C57BLMitochondriaPhosphorylationProtein Kinase C-epsilonSignal TransductionGlucoseGlycerolInsulinProtein Kinase C-epsilonReceptor, Insulin
Identifiers
PMID42168167
PMCPMC13385832
What Socratic holds
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LicenceCC BY-NC-ND
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