Evidence map›Paper›PMID 42168643›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Visual versus quantitative tau-PET Braak staging in Alzheimer's disease using [

Arthur C Macedo, Karine Provost, Jean-Paul Soucy, Arlette Haeger, Joseph Therriault, Lydia Trudel, Nesrine Rahmouni, Jaime Fernandez-Arias, Étienne Aumont, Aurélie Lebrun and 17 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Arthur C Macedo *Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.ORCID 0000-0002-3957-0284
Karine Provost *Montreal Neurological Institute, Montréal, Québec, Canada.
Jean-Paul SoucyMontreal Neurological Institute, Montréal, Québec, Canada.
Arlette HaegerNuclear Medicine and PET/CT Center PositronMed, Santiago, Chile.
Joseph TherriaultTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Lydia TrudelTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Nesrine RahmouniTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Jaime Fernandez-AriasTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Étienne AumontTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Aurélie LebrunTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Tevy ChanTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Seyyed Ali HosseiniTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Gleb BezginTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Cécile TissotTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Stijn ServaesTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Brandon HallTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Jenna StevensonTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Robert HopewellPET Unit, McConnell Brain Imaging Centre, Montréal, QC, Canada.
Chris Hung-Hsin HsiaoPET Unit, McConnell Brain Imaging Centre, Montréal, QC, Canada.
Gallen Triana-BaltzerNeuroscience Biomarkers, Janssen Research & Development, La Jolla, CA, USA.
Hartmuth C KolbNeuroscience Biomarkers, Janssen Research & Development, La Jolla, CA, USA.
Andréa L BenedetDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Gassan MassarwehPET Unit, McConnell Brain Imaging Centre, Montréal, QC, Canada.
Jesse KlostranecMontreal Neurological Institute, Montréal, Québec, Canada.
Paolo VitaliTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada.
Tharick A PascoalDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute, 6875 LaSalle Blvd, Montréal, QC, H4H 1R3, Canada. pedro.rosa@mcgill.ca.

Funding

Alzheimer Society Research Program 0000000158Consortium canadien en neurodégénérescence associée au vieillissement MOP-11-51-31-team 1Fondation Brain Canada 33397Fondation Brain Canada CFI Project 34874Fonds de Recherche du Québec - Santé 2020-VICO-279314Fonds de Recherche du Québec - Santé 2024 VICO-356138Fonds de Recherche du Québec - Santé FRQSFonds de Recherche du Québec - Santé https://doi.org/10.69777/312994Fonds de Recherche du Québec - Santé https://doi.org/10.69777/324345Fonds de Recherche du Québec - Santé https://doi.org/10.69777/356138NINR NIH HHS 159815NINR NIH HHS 162303NINR NIH HHS MOP-11-51-31; RFN 152985
6 · The paper itself

Abstract

purposeThe 2024 Alzheimer's Association Workgroup research framework designates tau proteinopathy (T

methodsWe included 140 participants from the TRIAD cohort who underwent [

resultsvBraak demonstrated substantial to nearly perfect inter-rater agreement (κ = 0.65-0.93). Agreement between vBraak and qBraak was moderate when stages were treated categorically (κ = 0.51), but substantial when their ordinal nature was considered (weighted κ up to 0.73). Both strategies showed comparable associations with clinical severity and neurodegeneration. vBraak was more sensitive to amyloid-β-positive cognitive impairment and identified intermediate-stage involvement at lower global tau extent. Visual-quantitative discordant cases were primarily attributable to off-target binding or spatially heterogeneous tau patterns.

conclusionBoth vBraak and qBraak staging provide complementary and largely concordant approaches for operationalizing T

Indexed as

Alzheimer DiseasePositron-Emission Tomographytau ProteinsAgedAged, 80 and overFemaleFluorine RadioisotopesHumansIsoquinolinesMaleFluorine RadioisotopesIsoquinolinesMK-6240tau ProteinsAlzheimer diseaseBraak stagingDisease stagingNeurofibrillary tnglesPositron emission tomographyTau proteins

Identifiers

PMID42168643

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.