Evidence map›Paper›PMID 42168686›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2026

Study on the Mechanism of Berberine Reversing MRSA Resistance to β-Lactam Antibiotics by Inhibiting blaZ Expression.

Fangfang Zhou, Xuemei Gu, Ming Lin, Yue Dai, Yanan Li, Mingming Jiang, Bianba Yangzong, Ying Wang, Xiaochun Sun, Lei Wang

Abstract read
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In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fangfang Zhou *School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Xuemei Gu *Department of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai, China.
Ming LinDepartment of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai, China.
Yue DaiDepartment of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai, China.
Yanan LiDepartment of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai, China.
Mingming JiangDepartment of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai, China.
Bianba YangzongDepartment of Laboratory, Fokind Hospital Affiliated to Tibet University, Lhasa, China.
Ying WangDepartment of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai, China. gongzhuying@126.com.
Xiaochun SunSchool of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Lei WangSchool of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.

Funding

Key Medical Disciplines of Xuhui District，Shanghai SHXHZDXK202322Medical Research Projects of Shanghai Eighth People's Hospital SHBY202516Medical Research Projects of Shanghai Eighth People's Hospital SHBY202517
6 · The paper itself

Abstract

This study elucidates a novel mechanism by which the natural product berberine (BBR) reverses methicillin-resistant Staphylococcus aureus (MRSA) resistance to β-lactam antibiotics. It was established that BBR interferes with the BlaR1/BlaI regulatory pathway by means of downregulating the signal sensor gene blaR1 and the repressor gene blaI, thereby significantly suppressing the expression of the β-lactamase-encoding gene blaZ at the transcriptional level. The combination susceptibility testing demonstrated that BBR and Oxacillin exhibited synergistic or additive effects in 76.92% of the bacterial strains that were tested. This enhanced efficacy was closely associated with the presence of the blaZ gene. Molecular docking and dynamics simulations further confirmed that BBR stably binds to the active site of the BlaZ protein. These findings systematically clarify the multi-target mechanism of BBR as an antibiotic synergist and provide an important theoretical basis for developing combination therapeutic strategies against MRSA.

Indexed as

BerberineblaZMechanismMethicillin-resistant Staphylococcus aureus (MRSA)β-Lactam

Identifiers

PMID42168686

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.